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Rabbit Anti-SLAMF7 Antibody (CSB-PA021369ESR2HU)
Supplier: CUSABIO BIOTECH CO.
CD2 subset 1 Antibody,CD2-like receptor-activating cytotoxic cells Antibody,CRACC Antibody,Membrane protein FOAP-12 Antibody,Novel Ly9 Antibody,Protein 19A Antibody,CD319 Antibody,SLAMF7 Antibody,CS1 Antibody,UNQ576/PRO1138 AntibodyMore alternative names for the antibody
19A antibody|19A24 protein antibody|CD 319 antibody|CD2 like receptor activating cytotoxic cells antibody|CD2 subset 1 antibody|CD319 antibody|CD319 antigen antibody|CRACC antibody|CS1 antibody|Membrane protein FOAP 12 antibody|Novel Ly9 antibody|Novel LY9 (lymphocyte antigen 9) like protein antibody|Protein 19A antibody|SLAM family member 7 antibody|SLAMF 7 antibody
Anti-SLAMF7 antibody (ab202840)
Anti-SLAMF7 antibody (ab202840)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human SLAM family member 7 protein (23-226AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:57823( Human), Entrez Gene:75345( Mouse), Entrez Gene:364049( Rat), Omim:606625( Human), SwissProt:Q9NQ25( Human), SwissProt:Q8BHK6( Mouse), Unigene:517265( Human), Unigene:164642( Mouse), Unigene:228373( Rat)
|Protein function|| |
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528). .; Isoform 3 does not mediate any NK cell activation.
|Protein tissue specificity|| |
Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Expressed in monocytes. Isoform 3 is expressed at much lower level than isoform 1. .
|Protein sequence and domain|| |
The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A ‘three-pronged’ mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
|Protein cellular localization|| |
Membrane; Single-pass type I membrane protein.
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|Product type|| |
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