Anti-SLC46A1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-SLC46A1 Antibody (CSB-PA856995ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Proton-coupled folate transporter Antibody,G21 Antibody,Heme carrier protein 1 Antibody,PCFT/HCP1 Antibody,Solute carrier family 46 member 1 Antibody,SLC46A1 Antibody,HCP1 Antibody,PCFT Antibody

More alternative names for the antibody
G21 antibody|HCP 1 antibody|Heme carrier protein 1 antibody|MGC9564 antibody|PCFT antibody|PCFT/HCP1 antibody|PCFT_HUMAN antibody|PDE7A antibody|Proton coupled folate transporter antibody|Proton-coupled folate transporter antibody|SLC46A1 antibody|Solute carrier family 46 (folate transporter) member 1 antibody|Solute carrier family 46 member 1 antibody
Anti-HCP1 antibody (ab25134)
Close sc-393460|sc-54207|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-SLC46A1 Antibody

Catalogue No.

CSB-PA856995ESR1HU

Reactivity

Human

Immunogen

Recombinant human Proton-coupled folate transporter protein (1-130AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

49 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:113235( Human), Entrez Gene:52466( Mouse), Entrez Gene:303333( Rat), Omim:611672( Human), SwissProt:Q96NT5( Human), SwissProt:Q6PEM8( Mouse), SwissProt:Q5EBA8( Rat), Unigene:131618( Mouse), Unigene:153975( Rat)

Protein function

Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. .

Protein tissue specificity

Expressed in kidney, liver, placenta, small intestine, spleen, retina and retinal pigment epithelium. Lower levels found in colon and testis. Very low levels in brain, lung, stomach, heart and muscle. In intestine, expressed in duodenum with lower levels in jejunum, ileum, cecum, rectum and segments of the colon. .

Involvement in disease

Hereditary folate malabsorption (HFM) [MIM:229050]: Rare autosomal recessive disorder characterized by impaired intestinal folate absorption with folate deficiency resulting in anemia, hypoimmunoglobulinemia with recurrent infections, and recurrent or chronic diarrhea. In many patients, neurological abnormalities such as seizures or mental retardation become apparent during early childhood, attributed to impaired transport of folates into the central nervous system. When diagnosed early, the disorder can be treated by administration of folate. If untreated, it can be fatal and, if treatment is delayed, the neurological defects can become permanent. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the major facilitator superfamily. SLC46A family.

Protein cellular localization

Apical cell membrane; Multi-pass membrane protein. Cytoplasm . Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells. .

Research area

All research areas>Transport and Trafficking>HCP
(View all antibody categories related to Transport and Trafficking)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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