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Rabbit Anti-SLC46A1 Antibody (CSB-PA856995ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Proton-coupled folate transporter Antibody,G21 Antibody,Heme carrier protein 1 Antibody,PCFT/HCP1 Antibody,Solute carrier family 46 member 1 Antibody,SLC46A1 Antibody,HCP1 Antibody,PCFT AntibodyMore alternative names for the antibody
G21 antibody|HCP 1 antibody|Heme carrier protein 1 antibody|MGC9564 antibody|PCFT antibody|PCFT/HCP1 antibody|PCFT_HUMAN antibody|PDE7A antibody|Proton coupled folate transporter antibody|Proton-coupled folate transporter antibody|SLC46A1 antibody|Solute carrier family 46 (folate transporter) member 1 antibody|Solute carrier family 46 member 1 antibody
Anti-HCP1 antibody (ab25134)
Anti-HCP1 antibody (ab25134)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Proton-coupled folate transporter protein (1-130AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=113235" target="_blank">Entrez Gene:113235( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=52466" target="_blank">Entrez Gene:52466( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=303333" target="_blank">Entrez Gene:303333( Rat)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/611672" target="_blank">Omim:611672( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q96NT5" target="_blank">SwissProt:Q96NT5( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q6PEM8" target="_blank">SwissProt:Q6PEM8( Mouse)</a>, <a href="http://www.uniprot.org/uniprot/Q5EBA8" target="_blank">SwissProt:Q5EBA8( Rat)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=131618" target="_blank">Unigene:131618( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Rn&CID=153975" target="_blank">Unigene:153975( Rat)</a>
|Protein function|| |
Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. .
|Protein tissue specificity|| |
Expressed in kidney, liver, placenta, small intestine, spleen, retina and retinal pigment epithelium. Lower levels found in colon and testis. Very low levels in brain, lung, stomach, heart and muscle. In intestine, expressed in duodenum with lower levels in jejunum, ileum, cecum, rectum and segments of the colon. .
|Involvement in disease|| |
Hereditary folate malabsorption (HFM) [MIM:229050]: Rare autosomal recessive disorder characterized by impaired intestinal folate absorption with folate deficiency resulting in anemia, hypoimmunoglobulinemia with recurrent infections, and recurrent or chronic diarrhea. In many patients, neurological abnormalities such as seizures or mental retardation become apparent during early childhood, attributed to impaired transport of folates into the central nervous system. When diagnosed early, the disorder can be treated by administration of folate. If untreated, it can be fatal and, if treatment is delayed, the neurological defects can become permanent. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the major facilitator superfamily. SLC46A family.
|Protein cellular localization|| |
Apical cell membrane; Multi-pass membrane protein. Cytoplasm . Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells. .
|Research area|| |
<a href="https://antibodyplus.com/research-areas/">All research areas</a>><a href="https://antibodyplus.com/Transport-and-Trafficking/">Transport and Trafficking</a>><a href="https://antibodyplus.com/product-tag/HCP/">HCP</a><br><a href="https://antibodyplus.com/product-tag/Transport-and-Trafficking/"> (View all antibody categories related to Transport and Trafficking)</a>
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|Product type|| |
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