Anti-SMARCC2 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC,ChIP
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-SMARCC2 Antibody (CSB-PA851527ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

BRG1-associated factor 170 Antibody,BAF170 Antibody,SWI/SNF complex 170 kDa subunit Antibody,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 Antibody,SMARCC2 Antibody,BAF170 Antibody

More alternative names for the antibody
BAF 170 antibody|SWI3 like protein antibody
Anti-SMRC2 antibody (ab71907)
Close sc-9744|sc-17838|sc-166237|sc-10757|sc-9742|

Recommended applications: ELISA, WB, IHC, ChIP

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-SMARCC2 Antibody

Catalogue No.

CSB-PA851527ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human SWI/SNF complex subunit SMARCC2 protein (300-650AA)

Host

Rabbit

Applications

ELISA, WB, IHC, ChIP

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

132 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:6601( Human), Entrez Gene:68094( Mouse), Omim:601734( Human), SwissProt:Q8TAQ2( Human), SwissProt:Q6PDG5( Mouse), Unigene:236030( Human), Unigene:632717( Human), Unigene:417338( Mouse)

Protein function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). .

Protein tissue specificity

Ubiquitously expressed.

Protein sequence and domain

Belongs to the SMARCC family.

Protein cellular localization

Nucleus.

Research area

All research areas>Transcription Regulators>BAF
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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