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Rabbit Anti-SMC1A Antibody (CSB-PA614804ESR1HU)
Supplier: CUSABIO BIOTECH CO.
SMC protein 1A Antibody,SMC-1-alpha Antibody,SMC-1A Antibody,Sb1.8 Antibody,SMC1A Antibody,DXS423E Antibody, KIAA0178 Antibody, SB1.8 Antibody, SMC1 Antibody, SMC1L1 AntibodyMore alternative names for the antibody
Chromosome segregation protein SmcB antibody|DXS423E antibody|KIAA0178 antibody|MGC138332 antibody|Sb1.8 antibody|Segregation of mitotic chromosomes 1 antibody|SMC protein 1A antibody|SMC-1-alpha antibody|SMC-1A antibody|SMC1 (structural maintenance of chromosomes 1 yeast) like 1 antibody|SMC1 antibody|SMC1 structural maintenance of chromosomes 1 like 1 antibody|SMC1A antibody|SMC1A_HUMAN antibody|SMC1alpha antibody|SMC1L1 antibody|SMCB antibody|Structural maintenance of chromosomes 1A antibody|Structural maintenance of chromosomes protein 1A antibody
Anti-SMC1A antibody [EPFHCR37F] (ab133643)
Anti-SMC1A antibody [EPFHCR37F] (ab133643)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Structural maintenance of chromosomes protein 1A protein (1-130AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. .
|Involvement in disease|| |
Cornelia de Lange syndrome 2 (CDLS2) [MIM:300590]: A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. Characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the SMC family. SMC1 subfamily. The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity).
|Protein post-translational modifications|| |
Phosphorylated by ATM upon ionizing radiation in a NBS1-dependent manner. Phosphorylated by ATR upon DNA methylation in a MSH2/MSH6-dependent manner. Phosphorylation of Ser-957 and Ser-966 activates it and is required for S-phase checkpoint activation. .
|Protein cellular localization|| |
Nucleus . Chromosome . Chromosome, centromere, kinetochore . Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere-kinetochore complex at the kinetochore region during mitosis.
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CUSABIO BIOTECH CO.
|Product type|| |
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