Anti-SOCS5 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-SOCS5 Antibody (CSB-PA022394ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Suppressor of cytokine signaling 5 Antibody,SOCS-5 Antibody,Cytokine-inducible SH2 protein 6 Antibody,CIS-6 Antibody,Cytokine-inducible SH2-containing protein 5 Antibody,SOCS5 Antibody,CIS6 Antibody,CISH5 Antibody,CISH6 Antibody,KIAA0671 Antibody

More alternative names for the antibody
CIS-6 antibody|CIS6 antibody|CISH5 antibody|CISH6 antibody|Cytokine inducible SH2 containing protein 5 antibody|Cytokine inducible SH2 protein 6 antibody|KIAA0671 antibody|SOCS-5 antibody|Suppressor of cytokine signaling 5 antibody
Anti-SOCS5 antibody (ab3695)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-SOCS5 Antibody

Catalogue No.

CSB-PA022394ESR2HU

Reactivity

Human

Immunogen

Recombinant human Suppressor of cytokine signaling 5 protein (1-270AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

61 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:9655( Human), Entrez Gene:56468( Mouse), Omim:607094( Human), SwissProt:O75159( Human), SwissProt:O54928( Mouse), Unigene:468426( Human), Unigene:126885( Mouse)

Protein function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. .

Protein sequence and domain

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.

Protein post-translational modifications

Phosphorylated. Phosphorylation is induced by EGF. .

Research area

All research areas>Signaling Intermediates>SOCS
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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