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Rabbit Anti-SPAG5 Antibody (CSB-PA853491ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Astrin Antibody,Deepest Antibody,Mitotic spindle-associated protein p126 Antibody,MAP126 Antibody,SPAG5 AntibodyMore alternative names for the antibody
Astrin antibody|Mitotic spindle-associated protein p126 antibody|SPAG 5 antibody|SPAG5 antibody|SPAG5_HUMAN antibody|Sperm associated antigen 5 antibody|Sperm tail protein Spag 5 antibody|Sperm tail protein Spag5 antibody|Sperm-associated antigen 5 antibody
Anti-MAP126 antibody (ab214182)
Anti-MAP126 antibody (ab214182)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Sperm-associated antigen 5 protein (1-300AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:10615( Human), Entrez Gene:54141( Mouse), Entrez Gene:252918( Rat), Omim:615562( Human), SwissProt:Q96R06( Human), SwissProt:Q7TME2( Mouse), Unigene:514033( Human), Unigene:24250( Mouse), Unigene:154430( Rat)
|Protein function|| |
Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). .
|Protein tissue specificity|| |
Highly expressed in testis. Detected at low levels in placenta, liver, pancreas, thymus and colon. .
|Protein post-translational modifications|| |
Phosphorylated by AURKA. .
|Protein cellular localization|| |
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Note=Colocalizes with PCM1 at centriolar satellites throughout the cell cycle (PubMed:26297806). In a punctate pattern in interphase cells. During mitosis, detected at spindle poles during prophase, throughout the spindle in metaphase and anaphase, and at midzone microtubules in anaphase and telophase. Efficient targeting to the mitotic spindle may depend upon phosphorylation by GSK3B. Detected on kinetochores of chromosomes that have congressed. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends (By similarity). In non-mitotic non-stressed cells, shows a microtubuli pattern. In arsenite-stressed cells, accumulates in stress granules. .
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CUSABIO BIOTECH CO.
|Product type|| |
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