Anti-SPIN1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-SPIN1 Antibody (CSB-PA897305DSR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Spindlin-1 Antibody,Ovarian cancer-related protein Antibody,Spindlin1 Antibody,SPIN1 Antibody,OCR Antibody,SPIN Antibody

More alternative names for the antibody
OCR antibody|SPIN antibody|Spin1 antibody|SPIN1_HUMAN antibody|Spindlin-1 antibody
Anti-spindlin 1 antibody (ab196938)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-SPIN1 Antibody

Catalogue No.

CSB-PA897305DSR1HU

Reactivity

Human

Immunogen

Recombinant human Spindlin-1 protein (1-262AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

29 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:10927( Human), Entrez Gene:20729( Mouse), Entrez Gene:100173430( Orangutan), Entrez Gene:361217( Rat), Omim:609936( Human), SwissProt:Q9Y657( Human), SwissProt:Q61142( Mouse), SwissProt:Q5R997( Orangutan), SwissProt:Q4V8J7( Rat), Unigene:146804( Human), Unigene:188432( Mouse), Unigene:199017( Rat)

Protein function

Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at ‘Lys-4’ and asymmetrically dimethylated at ‘Arg-8’ (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. .

Protein tissue specificity

Highly expressed in ovarian cancer tissues. .

Protein sequence and domain

Belongs to the SPIN/STSY family. The 3 tudor-like domains (also named Spin/Ssty repeats) specifically recognize and bind methylated histones (PubMed:23077255, PubMed:24589551). H3K4me3 and H3R8me2a are recognized by tudor-like domains 2 and 1, respectively (PubMed:24589551).

Protein post-translational modifications

Phosphorylated during oocyte meiotic maturation. .

Protein cellular localization

Nucleus . Nucleus, nucleolus .

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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