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Rabbit Anti-SPTLC1 Antibody (CSB-PA022639ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Long chain base biosynthesis protein 1 Antibody,LCB 1 Antibody,Serine-palmitoyl-CoA transferase 1 Antibody,SPT 1 Antibody,SPTLC1 Antibody,LCB1 AntibodyMore alternative names for the antibody
HSAN antibody|HSAN1 antibody|HSN1 antibody|LBC1 antibody|LCB 1 antibody|LCB1 antibody|Long chain base biosynthesis protein 1 antibody|MGC14645 antibody|Serine C palmitoyltransferase antibody|Serine palmitoyl CoA transferase 1 antibody|Serine palmitoyltransferase 1 antibody|Serine palmitoyltransferase long chain base subunit 1 antibody|Serine palmitoyltransferase subunit 1 antibody|Serine-palmitoyl-CoA transferase 1 antibody|SPT 1 antibody|SPT1 antibody|SPTC1_HUMAN antibody|SPTI antibody|SPTLC 1 antibody|SPTLC1 antibody
Anti-SPTLC1 antibody (ab176706)
Anti-SPTLC1 antibody (ab176706)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Serine palmitoyltransferase 1 protein (37-310AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:426145( Chicken), Entrez Gene:739412( Chimpanzee), Entrez Gene:614165( Cow), Entrez Gene:100726468( Guinea pig), Entrez Gene:10558( Human), Entrez Gene:268656( Mouse), Entrez Gene:100344536( Rabbit), Entrez Gene:705324( Rhesus monkey), Omim:605712( Human), SwissProt:Q3MHG1( Cow), SwissProt:Q60HD1( Cynomolgus Monkey), SwissProt:O15269( Human), SwissProt:O35704( Mouse), Unigene:90458( Human), Unigene:240336( Mouse)
|Protein function|| |
Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. .
|Protein tissue specificity|| |
Widely expressed. Not detected in small intestine. .
|Involvement in disease|| |
Neuropathy, hereditary sensory and autonomic, 1A (HSAN1A) [MIM:162400]: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by prominent sensory abnormalities with a variable degree of motor and autonomic dysfunction. The neurological phenotype is often complicated by severe infections, osteomyelitis, and amputations. HSAN1A is an autosomal dominant axonal form with onset in the second or third decades. Initial symptoms are loss of pain, touch, heat, and cold sensation over the feet, followed by distal muscle wasting and weakness. Loss of pain sensation leads to chronic skin ulcers and distal amputations. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Note=SPTLC1 mutations at Ser-331 are responsible for severe hereditary motor and sensory neuropathy (HMSN) forms, whose core features are severe, diffuse muscle wasting and hypotonia, motor and sensory disturbances, foot ulcers, amputations and/or burns, joint hypermobility, cataracts and considerable growth retardation. .
|Protein sequence and domain|| |
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
|Protein post-translational modifications|| |
Phosphorylation at Tyr-164 inhibits activity and promotes cell survival. .
|Protein cellular localization|| |
Endoplasmic reticulum membrane ; Single-pass membrane protein .
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