Anti-STAT5B Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC,ChIP
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-STAT5B Antibody (CSB-PA022815ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

STAT5B Antibody

More alternative names for the antibody
Mammary gland factor (STAT5A) antibody|MGF (STAT5A) antibody|Signal transducer and activator of transcription 5A antibody|Signal transducer and activator of transcription 5B antibody|STA5A_HUMAN antibody|Stat 5a antibody|STAT 5b antibody|STAT5A antibody|Transcription factor STAT5B antibody
Anti-STAT 5A + B antibody [EPR16671-40] (ab194898)
Close sc-81524|sc-12893|sc-101806|sc-81525|sc-136019|sc-101808|sc-11762|

Recommended applications: ELISA, WB, IHC, ChIP

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-STAT5B Antibody

Catalogue No.

CSB-PA022815ESR1HU

Reactivity

Human

Immunogen

Recombinant human Signal transducer and activator of transcription 5B protein (40-280AA)

Host

Rabbit

Applications

ELISA, WB, IHC, ChIP

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

89 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:6776( Human), Entrez Gene:6777( Human), Entrez Gene:20850( Mouse), Entrez Gene:20851( Mouse), Entrez Gene:24918( Rat), Entrez Gene:25126( Rat), Omim:601511( Human), Omim:604260( Human), SwissProt:P42229( Human), SwissProt:P51692( Human), SwissProt:P42230( Mouse), SwissProt:P42232( Mouse), SwissProt:P52632( Rat), SwissProt:Q62771( Rat), Unigene:437058( Human), Unigene:277403( Mouse), Unigene:34064( Mouse), Unigene:154399( Rat), Unigene:54486( Rat)

Protein function

Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription (PubMed:11773439). Positively regulates hematopoietic/erythroid differentiation (PubMed:20702587). .

Involvement in disease

Growth hormone insensitivity with immunodeficiency (GHII) [MIM:245590]: A disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, resistance to hexogeneous growth hormone therapy, and recurrent infections. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the transcription factor STAT family.

Protein post-translational modifications

Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway. .

Protein cellular localization

Cytoplasm . Nucleus . Note=Translocated into the nucleus in response to phosphorylation. .

Research area

All research areas>Transcription Regulators>Stat
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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