Anti-STRAP Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-STRAP Antibody (CSB-PA896713ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

MAP activator with WD repeats Antibody,UNR-interacting protein Antibody,WD-40 repeat protein PT-WD Antibody,STRAP Antibody,MAWD Antibody,UNRIP Antibody

More alternative names for the antibody
MAP activator with WD repeats antibody|MAWD antibody|PTWD antibody|Serine-threonine kinase receptor-associated protein antibody|serine/threonine kinase receptor associated protein antibody|strap antibody|STRAP_HUMAN antibody|UNR-interacting protein antibody|UNRIP antibody|WD 40 repeat protein PT WD antibody|WD-40 repeat protein PT-WD antibody
Anti-Unrip antibody (ab102001)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-STRAP Antibody

Catalogue No.

CSB-PA896713ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Serine-threonine kinase receptor-associated protein (1-350AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

38 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:510201( Cow), Entrez Gene:11171( Human), Entrez Gene:20901( Mouse), Entrez Gene:297699( Rat), Omim:605986( Human), SwissProt:Q5E959( Cow), SwissProt:Q9Y3F4( Human), SwissProt:Q9Z1Z2( Mouse), SwissProt:Q5XIG8( Rat), Unigene:743971( Human), Unigene:22584( Mouse), Unigene:228807( Rat)

Protein function

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. .

Protein sequence and domain

Belongs to the WD repeat STRAP family.

Protein cellular localization

Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus.

Research area

All research areas>Signaling Intermediates>STRAP
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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