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Rabbit Anti-STRAP Antibody (CSB-PA896713ESR2HU)
Supplier: CUSABIO BIOTECH CO.
MAP activator with WD repeats Antibody,UNR-interacting protein Antibody,WD-40 repeat protein PT-WD Antibody,STRAP Antibody,MAWD Antibody,UNRIP AntibodyMore alternative names for the antibody
MAP activator with WD repeats antibody|MAWD antibody|PTWD antibody|Serine-threonine kinase receptor-associated protein antibody|serine/threonine kinase receptor associated protein antibody|strap antibody|STRAP_HUMAN antibody|UNR-interacting protein antibody|UNRIP antibody|WD 40 repeat protein PT WD antibody|WD-40 repeat protein PT-WD antibody
Anti-Unrip antibody (ab102001)
Anti-Unrip antibody (ab102001)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Serine-threonine kinase receptor-associated protein (1-350AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:510201( Cow), Entrez Gene:11171( Human), Entrez Gene:20901( Mouse), Entrez Gene:297699( Rat), Omim:605986( Human), SwissProt:Q5E959( Cow), SwissProt:Q9Y3F4( Human), SwissProt:Q9Z1Z2( Mouse), SwissProt:Q5XIG8( Rat), Unigene:743971( Human), Unigene:22584( Mouse), Unigene:228807( Rat)
|Protein function|| |
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. .
|Protein sequence and domain|| |
Belongs to the WD repeat STRAP family.
|Protein cellular localization|| |
Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus.
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CUSABIO BIOTECH CO.
|Product type|| |
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