Anti-SUFU Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-SUFU Antibody (CSB-PA891560ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

SUFUH Antibody,SUFU Antibody,UNQ650/PRO1280 Antibody

More alternative names for the antibody
OTTHUMP00000020374 antibody|OTTHUMP00000020377 antibody|OTTHUMP00000020379 antibody|PRO1280 antibody|SU FU antibody|SU(F)U antibody|Su(fu) antibody|SUFU antibody|SUFU negative regulator of hedgehog signaling antibody|SUFU_HUMAN antibody|SUFUH antibody|SUFUXL antibody|Suppressor of fused homolog (Drosophila) antibody|Suppressor of fused homolog antibody
Anti-Suppressor of Fused antibody (ab28083)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-SUFU Antibody

Catalogue No.

CSB-PA891560ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Suppressor of fused homolog protein (325-484AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

53 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:374118( Chicken), Entrez Gene:51684( Human), Entrez Gene:24069( Mouse), Entrez Gene:361769( Rat), Omim:607035( Human), SwissProt:Q9UMX1( Human), SwissProt:Q9Z0P7( Mouse), Unigene:404089( Human), Unigene:41210( Mouse), Unigene:211670( Rat)

Protein function

Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes (PubMed:15367681, PubMed:24311597, PubMed:24217340). Down-regulates GLI2-mediated transactivation of target genes (PubMed:24311597, PubMed:24217340). Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10806483, PubMed:24217340). Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for normal embryonic development. Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity). .

Protein tissue specificity

Ubiquitous in adult tissues. Detected in osteoblasts of the perichondrium in the developing limb of 12-week old embryos. Isoform 1 is detected in fetal brain, lung, kidney and testis. Isoform 2 is detected in fetal testis, and at much lower levels in fetal brain, lung and kidney. .

Involvement in disease

Medulloblastoma (MDB) [MIM:155255]: Malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the SUFU family.

Protein cellular localization

Cytoplasm . Nucleus .

Research area

All research areas>Signaling Intermediates>Su(fu)
(View all antibody categories related to Signaling Intermediates)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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