Anti-SUPT4H1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-SUPT4H1 Antibody (CSB-PA022957ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Transcription elongation factor SPT4 Antibody,hSPT4 Antibody,DRB sensitivity-inducing factor 14 kDa subunit Antibody,DSIF p14 Antibody,DRB sensitivity-inducing factor small subunit Antibody,DSIF small subunit Antibody,SUPT4H1 Antibody,SPT4H Antibody,SUPT4H Antibody

More alternative names for the antibody
DRB sensitivity-inducing factor 14 kDa subunit antibody|DRB sensitivity-inducing factor small subunit antibody|DSIF p14 antibody|DSIF small subunit antibody|hSPT4 antibody|SPT4 antibody|SPT4H antibody|SPT4H_HUMAN antibody|SUPT4H `1 antibody|SUPT4H antibody|Supt4h1 antibody|Transcription elongation factor spt4 antibody
Anti-Suppressor of Ty 4 homolog 1 antibody [EPR6100(2)] (ab129187)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-SUPT4H1 Antibody

Catalogue No.

CSB-PA022957ESR2HU

Reactivity

Human

Immunogen

Recombinant human Transcription elongation factor SPT4 protein (1-117AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

13 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:6827( Human), Entrez Gene:20922( Mouse), Entrez Gene:287608( Rat), Omim:603555( Human), SwissProt:P63272( Human), SwissProt:P63271( Mouse), SwissProt:B5DEM7( Rat), Unigene:439481( Human), Unigene:622( Mouse), Unigene:7906( Rat)

Protein function

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3′ terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences. .

Protein tissue specificity

Widely expressed. .

Protein sequence and domain

Belongs to the SPT4 family.

Protein cellular localization

Nucleus .

Research area

All research areas>Transcription Regulators>Suppressor of Ty
(View all antibody categories related to Transcription Regulators)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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