Anti-SUV39H2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-SUV39H2 Antibody (CSB-PA872500ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Histone H3-K9 methyltransferase 2 Antibody,H3-K9-HMTase 2 Antibody,Lysine N-methyltransferase 1B Antibody,Suppressor of variegation 3-9 homolog 2 Antibody,Su(var)3-9 homolog 2 Antibody,SUV39H2 Antibody,KMT1B Antibody

More alternative names for the antibody
FLJ23414 antibody|H3 K9 HMTase 2 antibody|H3-K9-HMTase 2 antibody|Histone H3 K9 methyltransferase 2 antibody|Histone H3-K9 methyltransferase 2 antibody|Histone lysine N methyltransferase H3 lysine 9 specific 2 antibody|Histone lysine N methyltransferase SUV39H2 antibody|Histone-lysine N-methyltransferase SUV39H2 antibody|KMT1B antibody|Lysine N methyltransferase 1B antibody|Lysine N-methyltransferase 1B antibody|sSuppressor of variegation 3 9 homolog 2 (Drosophila) antibody|Su(var)3 9 Drosophila homolog of 2 antibody|Su(var)3 9 homolog 2 antibody|Su(var)3-9 homolog 2 antibody|Suppressor of variegation 3 9 homolog 2 antibody|Suppressor of variegation 3-9 homolog 2 antibody|Suv39h2 antibody|SUV92_HUMAN antibody
Anti-KMT1B / SUV39H2 antibody [EPR18495] (ab190870)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-5000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-SUV39H2 Antibody

Catalogue No.

CSB-PA872500ESR2HU

Reactivity

Human

Immunogen

Recombinant human Histone-lysine N-methyltransferase SUV39H2 protein (201-410AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-5000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

46 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:79723( Human), Entrez Gene:64707( Mouse), Entrez Gene:364785( Rat), Omim:606503( Human), SwissProt:Q9H5I1( Human), SwissProt:Q9EQQ0( Mouse), Unigene:554883( Human), Unigene:128273( Mouse), Unigene:23483( Mouse), Unigene:154750( Rat)

Protein function

Histone methyltransferase that specifically trimethylates ‘Lys-9’ of histone H3 using monomethylated H3 ‘Lys-9’ as substrate. H3 ‘Lys-9’ trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 ‘Lys-9’ trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 ‘Lys-9’ trimethylation. .

Protein sequence and domain

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity).; In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.

Protein cellular localization

Nucleus . Chromosome, centromere . Note=Associates with centromeric constitutive heterochromatin. .

Research area

All research areas>Transcription Regulators>SUV39H
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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