Anti-TACR3 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Anti-TACR3 Antibody (CSB-PA023070ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Neuromedin-K receptor Antibody,NKR Antibody,NK-3 receptor Antibody,NK-3R Antibody,Neurokinin B receptor Antibody,Tachykinin receptor 3 Antibody,TACR3 Antibody,NK3R Antibody,TAC3R Antibody

More alternative names for the antibody
MGC148060 antibody|MGC148061 antibody|neurokinin 3 receptor antibody|Neurokinin B antibody|neurokinin b receptor antibody|Neuromedin K Receptor antibody|nk-3 receptor antibody|NK-3R antibody|NK3 Receptor antibody|NK3R antibody|NKR antibody|nmk-r antibody|TAC3R antibody|TAC3RL antibody|Tachykinin receptor 3 antibody|TACR3 antibody
Anti-Neurokinin 3 Receptor NK3 antibody (ab124025)
Close sc-28952|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TACR3 Antibody

Catalogue No.

CSB-PA023070ESR2HU

Reactivity

Human

Immunogen

Recombinant human Neuromedin-K receptor protein (356-465AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

52 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:6870( Human), Entrez Gene:21338( Mouse), Omim:162332( Human), SwissProt:P29371( Human), SwissProt:P47937( Mouse), Unigene:942( Human), Unigene:103810( Mouse)

Protein function

This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.

Involvement in disease

Hypogonadotropic hypogonadism 11 with or without anosmia (HH11) [MIM:614840]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). . Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in TACR3 as well as in other HH-associated genes including FGFR1, SPRY4 and KAL1 (PubMed:23643382). .

Protein sequence and domain

Belongs to the G-protein coupled receptor 1 family.

Protein post-translational modifications

The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.

Protein cellular localization

Cell membrane; Multi-pass membrane protein.

Research area

All research areas>Neurobiology Antibodies>NK
(View all antibody categories related to Neurobiology Antibodies)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!