Anti-TAP1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TAP1 Antibody (CSB-PA023120ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

APT1 Antibody,ATP-binding cassette sub-family B member 2 Antibody,Peptide supply factor 1 Antibody,Peptide transporter PSF1 Antibody,PSF-1 Antibody,Peptide transporter TAP1 Antibody,Peptide transporter involved in antigen processing 1 Antibody,Really interesting new gene 4 protein Antibody,TAP1 Antibody,ABCB2 Antibody, PSF1 Antibody, RING4 Antibody,Y3 Antibody

More alternative names for the antibody
ABC 17 antibody|ABC transporter MHC 1 antibody|ABC17 antibody|ABCB 2 antibody|ABCB2 antibody|Antigen peptide transporter 1 antibody|APT 1 antibody|APT1 antibody|ATP binding cassette sub family B (MDR/TAP) member 2 antibody|ATP binding cassette sub family B member 2 antibody|ATP binding cassette transporter antibody|ATP-binding cassette sub-family B member 2 antibody|D6S114E antibody|FLJ26666 antibody|FLJ41500 antibody|Peptide supply factor 1 antibody|Peptide transporter involved in antigen processing 1 antibody|Peptide transporter PSF 1 antibody|Peptide transporter PSF1 antibody|Peptide transporter TAP 1 antibody|Peptide transporter TAP1 antibody|PSF 1 antibody|PSF-1 antibody|PSF1 antibody|Really interesting new gene 4 protein antibody|RING 4 antibody|RING4 antibody|TAP 1 antibody|TAP1 antibody|TAP1*0102N antibody|TAP1_HUMAN antibody|TAP1N antibody|Transporter 1 ATP binding cassette sub family B (MDR/TAP) antibody|Transporter 1 ATP binding cassette sub family B antibody|Transporter associated with antigen processing antibody|Transporter ATP binding cassette major histocompatibility complex 1 antibody|Y3 antibody
Anti-TAP1 antibody (ab13516)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TAP1 Antibody

Catalogue No.

CSB-PA023120ESR1HU

Reactivity

Human

Immunogen

Recombinant human Antigen peptide transporter 1 protein (524-808AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

87 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:6890( Human), Entrez Gene:24811( Rat), Omim:170260( Human), SwissProt:Q03518( Human), SwissProt:P36370( Rat), Unigene:352018( Human), Unigene:10763( Rat)

Protein function

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

Involvement in disease

Bare lymphocyte syndrome 1 (BLS1) [MIM:604571]: A HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.

Protein cellular localization

Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane.

Research area

All research areas>Lymphocyte Signaling>Tapasin
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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