Anti-TARDBP Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TARDBP Antibody (CSB-PA621652ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

TDP-43 Antibody,TARDBP Antibody,TDP43 Antibody

More alternative names for the antibody
ALS10 antibody|OTTHUMP00000002171 antibody|OTTHUMP00000002172 antibody|OTTHUMP00000002173 antibody|TADBP_HUMAN antibody|TAR DNA binding protein 43 antibody|TAR DNA binding protein antibody|TAR DNA-binding protein 43 antibody|TARDBP antibody|TDP 43 antibody|TDP-43 antibody|TDP43 antibody
Anti-TDP43 antibody [2E2-D3] (ab57105)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-5000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TARDBP Antibody

Catalogue No.

CSB-PA621652ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human TARDBP protein (1-260AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-5000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

44 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:23435( Human), Omim:605078( Human), SwissProt:Q13148( Human), Unigene:300624( Human), Unigene:635053( Human)

Protein function

DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3′-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3′ UTR. .

Protein tissue specificity

Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.

Involvement in disease

Amyotrophic lateral sclerosis 10 (ALS10) [MIM:612069]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

The RRM domains can bind to both DNA and RNA.

Protein post-translational modifications

Hyperphosphorylated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.; Ubiquitinated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU. .; Cleaved to generate C-terminal fragments in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.

Protein cellular localization

Nucleus . Note=In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies.

Research area

All research areas>Signaling Intermediates>TARDBP
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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