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Rabbit Anti-TDP1 Antibody (CSB-PA023352ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Tyr-DNA phosphodiesterase 1 Antibody,TDP1 AntibodyMore alternative names for the antibody
AI838772 antibody|AW493413 antibody|FLJ11090 antibody|MGC104252 antibody|MGC112732 antibody|RP24-311F12.2 antibody|SCAN1 antibody|TDP1 antibody|TYDP antibody|TYDP1_HUMAN antibody|Tyr-DNA phosphodiesterase 1 antibody|Tyrosyl-DNA phosphodiesterase 1 antibody
Anti-TDP1 antibody (ab4166)
Anti-TDP1 antibody (ab4166)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Tyrosyl-DNA phosphodiesterase 1 protein (1-260AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:55775( Human), Entrez Gene:104884( Mouse), Entrez Gene:314380( Rat), Omim:607198( Human), SwissProt:Q9NUW8( Human), SwissProt:Q8BJ37( Mouse), SwissProt:Q4G056( Rat), Unigene:209945( Human), Unigene:312323( Mouse), Unigene:487464( Mouse), Unigene:488658( Mouse), Unigene:12661( Rat)
|Protein function|| |
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3′-phosphodiester bond, giving rise to DNA with a free 3′ phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3′-phosphoglycolates on protruding 3′ ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3’exonuclease activity and can remove a single nucleoside from the 3’end of DNA and RNA molecules with 3’hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3’phosphate. .
|Protein tissue specificity|| |
Ubiquitously expressed. Similar expression throughout the central nervous system (whole brain, amygdala, caudate nucleus, cerebellum, cerebral cortex, frontal lobe, hippocampus, medulla oblongata, occipital lobe, putamen, substantia nigra, temporal lobe, thalamus, nucleus accumbens and spinal cord) and increased expression in testis and thymus. .
|Involvement in disease|| |
Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy (SCAN1) [MIM:607250]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAN1 is an autosomal recessive cerebellar ataxia (ARCA) associated with peripheral axonal motor and sensory neuropathy, distal muscular atrophy, pes cavus and steppage gait as seen in Charcot-Marie-Tooth neuropathy. All affected individuals have normal intelligence. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the tyrosyl-DNA phosphodiesterase family.
|Protein post-translational modifications|| |
Phosphorylated on serine and/or threonine residues, but not on tyrosine residues. .
|Protein cellular localization|| |
Nucleus . Cytoplasm .
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CUSABIO BIOTECH CO.
|Product type|| |
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