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Rabbit Anti-TERF1 Antibody (CSB-PA023386ESR2HU)
Supplier: CUSABIO BIOTECH CO.
NIMA-interacting protein 2 Antibody,TTAGGG repeat-binding factor 1 Antibody,Telomeric protein Pin2/TRF1 Antibody,TERF1 Antibody,PIN2 Antibody, TRBF1 Antibody, TRF Antibody, TRF1 AntibodyMore alternative names for the antibody
hTRF1 AS antibody|NIMA interacting protein 2 antibody|NIMA-interacting protein 2 antibody|PIN 2 antibody|PIN2 antibody|t TRF1 antibody|Telomeric protein Pin2 antibody|Telomeric protein Pin2/TRF1 antibody|Telomeric repeat binding factor (NIMA interacting) 1 antibody|Telomeric repeat binding factor 1 antibody|Telomeric repeat binding protein 1 antibody|Telomeric repeat-binding factor 1 antibody|TERF 1 antibody|Terf1 antibody|TERF1_HUMAN antibody|TRBF 1 antibody|TRBF1 antibody|TRF 1 antibody|TRF antibody|TTAGGG repeat binding factor 1 antibody|TTAGGG repeat-binding factor 1 antibody
Anti-TRF1 antibody [TRF-78] (ab10579)
Anti-TRF1 antibody [TRF-78] (ab10579)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:200-1000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Telomeric repeat-binding factor 1 protein (260-439AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7013" target="_blank">Entrez Gene:7013( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/600951" target="_blank">Omim:600951( Human)</a>, <a href="http://www.uniprot.org/uniprot/P54274" target="_blank">SwissProt:P54274( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=442707" target="_blank">Unigene:442707( Human)</a>
|Protein function|| |
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. .
|Protein tissue specificity|| |
Highly expressed and ubiquitous. Isoform Pin2 predominates.
|Protein sequence and domain|| |
The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules.; The TRFH dimerization region mediates the interaction with TINF2.; The HTH domain is an independent structural unit and mediates binding to telomeric DNA.
|Protein post-translational modifications|| |
Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage. .; ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA.; Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex, leading to its degradation by the proteasome. .
|Protein cellular localization|| |
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.
|Research area|| |
<a href="https://antibodyplus.com/research-areas/">All research areas</a>><a href="https://antibodyplus.com/Transcription-Regulators/">Transcription Regulators</a>><a href="https://antibodyplus.com/product-tag/TRF/">TRF</a><br><a href="https://antibodyplus.com/product-tag/Transcription-Regulators/"> (View all antibody categories related to Transcription Regulators)</a>
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CUSABIO BIOTECH CO.
|Product type|| |
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