Anti-TERF1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TERF1 Antibody (CSB-PA023386ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

NIMA-interacting protein 2 Antibody,TTAGGG repeat-binding factor 1 Antibody,Telomeric protein Pin2/TRF1 Antibody,TERF1 Antibody,PIN2 Antibody, TRBF1 Antibody, TRF Antibody, TRF1 Antibody

More alternative names for the antibody
hTRF1 AS antibody|NIMA interacting protein 2 antibody|NIMA-interacting protein 2 antibody|PIN 2 antibody|PIN2 antibody|t TRF1 antibody|Telomeric protein Pin2 antibody|Telomeric protein Pin2/TRF1 antibody|Telomeric repeat binding factor (NIMA interacting) 1 antibody|Telomeric repeat binding factor 1 antibody|Telomeric repeat binding protein 1 antibody|Telomeric repeat-binding factor 1 antibody|TERF 1 antibody|Terf1 antibody|TERF1_HUMAN antibody|TRBF 1 antibody|TRBF1 antibody|TRF 1 antibody|TRF antibody|TTAGGG repeat binding factor 1 antibody|TTAGGG repeat-binding factor 1 antibody
Anti-TRF1 antibody [TRF-78] (ab10579)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TERF1 Antibody

Catalogue No.

CSB-PA023386ESR1HU

Reactivity

Human

Immunogen

Recombinant human Telomeric repeat-binding factor 1 protein (260-439AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

50 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:7013( Human), Omim:600951( Human), SwissProt:P54274( Human), Unigene:442707( Human)

Protein function

Binds the telomeric double-stranded 5′-TTAGGG-3′ repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5′-TTAGGG-3′ repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. .

Protein tissue specificity

Highly expressed and ubiquitous. Isoform Pin2 predominates.

Protein sequence and domain

The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules.; The TRFH dimerization region mediates the interaction with TINF2.; The HTH domain is an independent structural unit and mediates binding to telomeric DNA.

Protein post-translational modifications

Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage. .; ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA.; Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex, leading to its degradation by the proteasome. .

Protein cellular localization

Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.

Research area

All research areas>Transcription Regulators>TRF
(View all antibody categories related to Transcription Regulators)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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