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Rabbit Anti-TERF2IP Antibody (CSB-PA878922DSR2HU)
Supplier: CUSABIO BIOTECH CO.
TERF2-interacting telomeric protein 1 Antibody,TRF2-interacting telomeric protein 1 Antibody,Dopamine receptor-interacting protein 5 Antibody,Repressor/activator protein 1 homolog Antibody,RAP1 homolog Antibody,hRap1 Antibody,TERF2IP Antibody,DRIP5 Antibody,RAP1 AntibodyMore alternative names for the antibody
Dopamine receptor interacting protein 5 antibody|Dopamine receptor-interacting protein 5 antibody|DRIP 5 antibody|DRIP5 antibody|hRap1 antibody|MGC105533 antibody|RAP 1 antibody|RAP1 homolog antibody|RAP1, yeast, homolog if antibody|RAP1, yeast, homolog of antibody|Repressor/activator protein 1 homolog antibody|TE2IP_HUMAN antibody|Telomeric Repeat Binding Factor 2 Interacting Protein antibody|Telomeric repeat-binding factor 2-interacting protein 1 antibody|TERF2-interacting protein antibody|TERF2-interacting telomeric protein 1 antibody|TERF2IP antibody|TRF2 Interacting Telomeric Protein RAP1 antibody|TRF2 interacting telomeric RAP1 protein antibody|TRF2-interacting telomeric protein 1 antibody|TRF2-interacting telomeric protein antibody
Anti-RAP1 antibody [4c8/1] (ab14404)
Anti-RAP1 antibody [4c8/1] (ab14404)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Telomeric repeat-binding factor 2-interacting protein 1 protein (1-280AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5′-TTAGGG-3′ repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5′-TTAGGG-3′ sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. .
|Protein tissue specificity|| |
Ubiquitous. Highly expressed.
|Protein sequence and domain|| |
Belongs to the RAP1 family.
|Protein cellular localization|| |
Nucleus . Cytoplasm . Chromosome . Chromosome, telomere . Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex. .
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CUSABIO BIOTECH CO.
|Product type|| |
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