Anti-TFEB Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TFEB Antibody (CSB-PA023429ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Class E basic helix-loop-helix protein 35 Antibody,bHLHe35 Antibody,TFEB Antibody,BHLHE35 Antibody

More alternative names for the antibody
Alpha TFEB antibody|AlphaTFEB antibody|bHLHe35 antibody|Class E basic helix-loop-helix protein 35 antibody|T cell transcription factor EB antibody|TCFEB antibody|TFEB antibody|TFEB_HUMAN antibody|Transcription factor EB antibody
Anti-TFEB antibody – ChIP Grade (ab2636)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TFEB Antibody

Catalogue No.

CSB-PA023429ESR2HU

Reactivity

Human

Immunogen

Recombinant human Transcription factor EB protein (1-220AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

52 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:510032( Cow), Entrez Gene:609046( Dog), Entrez Gene:7942( Human), Entrez Gene:21425( Mouse), Entrez Gene:100157940( Pig), Entrez Gene:316214( Rat), Omim:600744( Human), SwissProt:P19484( Human), SwissProt:Q9R210( Mouse), Unigene:485360( Human), Unigene:715310( Human), Unigene:2305( Mouse), Unigene:22098( Rat)

Protein function

Transcription factor that specifically recognizes and binds E-box sequences (5′-CANNTG-3′). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5′-GTCACGTGAC-3′) present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. .

Protein sequence and domain

Belongs to the MiT/TFE family. The leucin zipper region is essential for homo- or heterodimerization and high-affinity DNA binding. DNA binding is mediated by the basic region.

Protein post-translational modifications

Sumoylated; does not affect dimerization with MITF. .

Protein cellular localization

Cytoplasm . Nucleus . Note=Mainly present in the cytoplasm (PubMed:23434374). Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus (PubMed:23434374). In macrophages, translocates into the nucleus upon live S.enterica infection (PubMed:27184844). .

Research area

All research areas>Transcription Regulators>TFE
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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