Anti-TGFBI Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TGFBI Antibody (CSB-PA618988ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Beta ig-h3 Antibody,Kerato-epithelin Antibody,RGD-containing collagen-associated protein Antibody,RGD-CAP Antibody,TGFBI Antibody,BIGH3 Antibody

More alternative names for the antibody
RGD containing collagen associated protein antibody|AI181842 antibody|AI747162 antibody|Beta ig antibody|Beta ig h3 antibody|Beta ig-h3 antibody|BGH3_HUMAN antibody|Big h3 antibody|BIGH3 antibody|CDB1 antibody|CDG2 antibody|CDGG1 antibody|CSD antibody|CSD1 antibody|CSD2 antibody|CSD3 antibody|EBMD antibody|Kerato epithelin antibody|Kerato-epithelin antibody|LCD1 antibody|MGC150270 antibody|RGD CAP antibody|RGD-CAP antibody|RGD-containing collagen-associated protein antibody|TGFBI antibody|TGFBI transforming growth factor, beta induced, 68kDa antibody|Transforming growth factor beta induced protein ig h3 antibody|Transforming growth factor-beta-induced protein ig-h3 antibody
Anti-TGFBI antibody [EPR12078(B)] (ab170874)
Close sc-14742|sc-28660|sc-14741|sc-14743|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TGFBI Antibody

Catalogue No.

CSB-PA618988ESR1HU

Reactivity

Human

Immunogen

Recombinant human Transforming growth factor-beta-induced protein ig-h3 protein (30-250AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

74 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:7045( Human), Entrez Gene:21810( Mouse), Entrez Gene:116487( Rat), Omim:601692( Human), SwissProt:Q15582( Human), SwissProt:P82198( Mouse), Unigene:369397( Human), Unigene:14455( Mouse), Unigene:1046( Rat)

Protein function

Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity). .

Protein tissue specificity

Highly expressed in the corneal epithelium (PubMed:27609313, PubMed:8077289). Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas (PubMed:8077289). .

Involvement in disease

Corneal dystrophy, epithelial basement membrane (EBMD) [MIM:121820]: A bilateral anterior corneal dystrophy characterized by grayish epithelial fingerprint lines, geographic map-like lines, and dots (or microcysts) on slit-lamp examination. Pathologic studies show abnormal, redundant basement membrane and intraepithelial lacunae filled with cellular debris. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Corneal dystrophy, Groenouw type 1 (CDGG1) [MIM:121900]: A rare form of stromal corneal dystrophy characterized by multiple small deposits in the superficial central corneal stroma, and progressive visual impairment. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Corneal dystrophy, lattice type 1 (CDL1) [MIM:122200]: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. CDL1 is characterized by progressive visual impairment, and the presence of delicate, double-contoured, interdigitating, elongated deposits that form a reticular pattern in the corneal stroma. Systemic amyloidosis is absent. Recurrent corneal ulceration sometimes occurs. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Corneal dystrophy, Thiel-Behnke type (CDTB) [MIM:602082]: A bilateral disorder of the cornea characterized by progressive honeycomb-like, subepithelial corneal opacities with recurrent erosions. Note=The disease is caused by mutations affecting the gene represented in this entry.; Corneal dystrophy, Reis-Bucklers type (CDRB) [MIM:608470]: A bilateral disorder of the cornea characterized by intermittent attacks of ocular irritation, recurrent painful corneal erosions starting in childhood, corneal opacities in a geographic pattern at the level of the Bowman layer, and a progressive decrease of visual acuity. The lesions are primarily in Bowman membrane with secondary involvement of the epithelium and superficial part of the stroma. Bowman membrane is almost completely replaced by pathologic materials including disoriented collagen fibrils. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Corneal dystrophy, lattice type 3A (CDL3A) [MIM:608471]: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. CDL3A is characterized by decreased visual acuity, and the presence of thick, ropy branching lattice lines and accumulations of amyloid deposits in the corneal stroma. Systemic amyloidosis is absent. CDL3A clinically resembles to lattice corneal dystrophy type 3, but differs in that its age of onset is 70 to 90 years. It has an autosomal dominant inheritance pattern. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Corneal dystrophy, Avellino type (CDA) [MIM:607541]: A corneal disease resulting in reduced visual acuity and characterized by gray, crumb-like granular deposits in the anterior third of the stroma in each corneal button. Fusiform amyloid deposits, histochemically and morphologically identical to those of lattice corneal dystrophy, are found in the deeper stroma. Additional features include recurrent corneal erosions, and glare and decreased night vision. Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein post-translational modifications

Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; these residues may be required for binding to calcium (PubMed:18450759). According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues (PubMed:26273833). .; The EMI domain contains 2 expected intradomain disulfide bridges (Cys-49-Cys85 and Cys-84-Cys-97) and one unusual interdomain disulfide bridge to the second FAS1 domain (Cys-74-Cys-339). This arrangement violates the predicted disulfide bridge pattern of an EMI domain. .

Protein cellular localization

Secreted . Secreted, extracellular space, extracellular matrix . Note=May be associated both with microfibrils and with the cell surface (PubMed:8077289). .

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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