Anti-THBD Antibody

$99.00$319.00

Reactivity: Human,Mouse,Rat
Applications: ELISA,WB
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-THBD Antibody (CSB-PA023486DSR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Thrombomodulin Antibody,TM Antibody,Fetomodulin Antibody,CD141 Antibody,THBD Antibody,THRM Antibody

More alternative names for the antibody
AHUS 6 antibody|AHUS6 antibody|BDCA 3 antibody|BDCA3 antibody|CD 141 antibody|CD141 antibody|CD141 antigen antibody|Fetomodulin antibody|Thbd antibody|THPH12 antibody|THRM antibody|Thrombomodulin antibody|TM antibody|TRBM_HUMAN antibody
Anti-Thrombomodulin antibody [EPR4051] (ab109189)
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Recommended applications: ELISA, WB

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-THBD Antibody

Catalogue No.

CSB-PA023486DSR1HU

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant human Thrombomodulin protein (200-500AA)

Host

Rabbit

Applications

ELISA, WB

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

60 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:7056( Human), Omim:188040( Human), SwissProt:P07204( Human), Unigene:2030( Human)

Protein function

Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

Protein tissue specificity

Endothelial cells are unique in synthesizing thrombomodulin.

Involvement in disease

Thrombophilia due to thrombomodulin defect (THPH12) [MIM:614486]: A hemostatic disorder characterized by a tendency to thrombosis. . Note=The disease may be caused by mutations affecting the gene represented in this entry. The role of thrombomodulin in thrombosis is controversial. It is likely that genetic or environmental risk factors in addition to THBD variation are involved in the pathogenesis of venous thrombosis.; Hemolytic uremic syndrome atypical 6 (AHUS6) [MIM:612926]: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Other genes may play a role in modifying the phenotype.

Protein sequence and domain

Extracellular region (481-515) contains a binding side for alpha-L/beta-2 and alpha-M/beta-2 integrin.

Protein post-translational modifications

N-glycosylated. .; The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. .

Protein cellular localization

Membrane; Single-pass type I membrane protein.

Research area

All research areas>Lymphocyte Signaling>TM
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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