Anti-THOC1 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC,ChIP
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-THOC1 Antibody (CSB-PA853419ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Tho1 Antibody,Nuclear matrix protein p84 Antibody,p84N5 Antibody,hTREX84 Antibody,THOC1 Antibody,HPR1 Antibody

More alternative names for the antibody
hTREX84 antibody|Death domain containing protein p84N5 antibody|HPR 1 antibody|HPR1 antibody|hTREX84 antibody|Nuclear matrix protein p84 antibody|P84 antibody|p84N5 antibody|Tho 1 antibody|THO complex 1 antibody|THO complex subunit 1 antibody|Tho1 antibody|THOC 1 antibody|Thoc1 antibody|THOC1_HUMAN antibody
Anti-Nuclear Matrix Protein p84 antibody [5E10] (ab487)
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Recommended applications: ELISA, WB, IHC, ChIP

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-THOC1 Antibody

Catalogue No.

CSB-PA853419ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human THO complex subunit 1 protein (428-657AA)

Host

Rabbit

Applications

ELISA, WB, IHC, ChIP

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

75 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:9984( Human), Entrez Gene:225160( Mouse), Omim:606930( Human), SwissProt:Q96FV9( Human), SwissProt:Q8R3N6( Mouse), Unigene:712543( Human), Unigene:219648( Mouse)

Protein function

Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5′ end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi’s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation.; Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.

Protein tissue specificity

Ubiquitous. Expressed in various cancer cell lines. Expressed at very low levels in normal breast epithelial cells and highly expressed in breast tumors. Expression is strongly associated with an aggressive phenotype of breast tumors and expression correlates with tumor size and the metastatic state of the tumor progression. .

Protein sequence and domain

An intact death domain is needed for apoptosis.

Protein post-translational modifications

Expression is altered specifically during apoptosis and is accompanied by the appearance of novel forms with smaller apparent molecular mass.; Polyubiquitinated, leading to proteasomal degradation; probably involves NEDD4. .

Protein cellular localization

Isoform 1: Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm. Note=Can shuttle between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution.; Isoform 2: Cytoplasm.

Research area

All research areas>Transcription Regulators>THOC
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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