Anti-TICAM2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TICAM2 Antibody (CSB-PA774830ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

TICAM-2;Putative NF-kappa-B-activating protein 502;TRIF-related adapter molecule;Toll-like receptor adaptor protein 3;Toll/interleukin-1 receptor domain-containing protein;MyD88-4;TICAM2;TIRAP3 Antibody, TIRP Antibody, TRAM Antibody

More alternative names for the antibody
Putative NF-kappa-B-activating protein 502 antibody|
Anti-TICAM2 antibody (ab17221)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TICAM2 Antibody

Catalogue No.

CSB-PA774830ESR2HU

Reactivity

Human

Immunogen

Recombinant human TIR domain-containing adapter molecule 2 protein (1-235AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

26 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:100302736( Human), Entrez Gene:353376( Human), Omim:608321( Human), SwissProt:Q86XR7( Human), Unigene:709120( Human)

Protein function

Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.; Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.

Protein tissue specificity

Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1). .

Protein sequence and domain

The TIR domain mediates the interaction with TRAF6 and MYD88.

Protein post-translational modifications

Phosphorylated by PRKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation. .; Isoform 1 is myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling. .

Protein cellular localization

Isoform 1: Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Note=Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane. Upon LPS stimulation colcoalizes with isoform 2 in late endosomes.; Isoform 2: Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Note=Translocates to late endosomes upon LPS stimulation where it colcoalizes with isoform 1.

Research area

All research areas>Lymphocyte Signaling>TICAM
(View all antibody categories related to Lymphocyte Signaling)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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