Anti-TIMM8A Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TIMM8A Antibody (CSB-PA023557ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Mitochondrial import inner membrane translocase subunit Tim8 A Antibody,Deafness dystonia protein 1 Antibody,X-linked deafness dystonia protein Antibody,TIMM8A Antibody,DDP Antibody,DDP1 Antibody,TIM8A Antibody

More alternative names for the antibody
DDP 1 antibody|DDP antibody|DDP1 antibody|Deafness dystonia protein 1 antibody|Deafness/dystonia peptide antibody|DFN 1 antibody|DFN1 antibody|MGC12262 antibody|Mitochondrial import inner membrane translocase subunit Tim8 A antibody|MTS antibody|TIM 8A antibody|TIM8 antibody|TIM8A antibody|TIM8A_HUMAN antibody|TIMM 8A antibody|timm8a antibody|Translocase of inner mitochondrial membrane 8 homolog A antibody|X linked deafness dystonia protein antibody|X-linked deafness dystonia protein antibody
Anti-TIMM8A antibody (ab168835)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TIMM8A Antibody

Catalogue No.

CSB-PA023557ESR2HU

Reactivity

Human

Immunogen

Recombinant human Mitochondrial import inner membrane translocase subunit Tim8 A protein (1-97AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

10 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:738690( Chimpanzee), Entrez Gene:101135568( Gorilla), Entrez Gene:1678( Human), Entrez Gene:30058( Mouse), Entrez Gene:100443133( Orangutan), Entrez Gene:702885( Rhesus monkey), GenBank:NP_004076( Human), Omim:300356( Human), SwissProt:O60220( Human), SwissProt:Q9WVA2( Mouse), Unigene:447877( Human), Unigene:214504( Mouse)

Protein function

Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development. .

Protein tissue specificity

Highly expressed in fetal and adult brain, followed by fetal lung, liver and kidney. Also expressed in heart, placenta, lung, liver, kidney, pancreas, skeletal muscle and heart.

Involvement in disease

Mohr-Tranebjaerg syndrome (MTS) [MIM:304700]: An X-linked recessive disorder characterized by postlingual sensorineural deafness with onset in early childhood, dystonia, spasticity, dysphagia, mental deterioration, paranoia and cortical blindness. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the small Tim family. The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8A from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

Protein cellular localization

Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side .

Research area

All research areas>Transport and Trafficking>Mitochondrial Import
(View all antibody categories related to Transport and Trafficking)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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