Anti-TIRAP Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TIRAP Antibody (CSB-PA023570ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

TIR domain-containing adapter protein Antibody,Adaptor protein Wyatt Antibody,MyD88 adapter-like protein Antibody,MyD88-2 Antibody,TIRAP Antibody,MAL Antibody

More alternative names for the antibody
Adapter protein wyatt antibody|FLJ42305 antibody|MAL antibody|MyD88 adapter like protein antibody|TIR domain containing adapter protein antibody|Toll interleukin 1 receptor (TIR) domain containing adaptor protein antibody|Toll interleukin 1 receptor domain containing adapter protein antibody|Toll like receptor adaptor protein antibody|Wyatt antibody
Anti-TIRAP antibody (ab17218)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TIRAP Antibody

Catalogue No.

CSB-PA023570ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Toll/interleukin-1 receptor domain-containing adapter protein (1-221AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

23 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:114609( Human), Entrez Gene:117149( Mouse), Entrez Gene:680127( Rat), GenBank:AF378129( Human), GenBank:AF378130( Human), Omim:606252( Human), SwissProt:P58753( Human), SwissProt:Q99JY1( Mouse), Unigene:537126( Human), Unigene:23987( Mouse)

Protein function

Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. .

Protein tissue specificity

Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.

Protein post-translational modifications

Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK.; Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation. .

Protein cellular localization

Cytoplasm . Cell membrane . Membrane . Note=Colocalizes with DAB2IP at the plasma membrane.

Research area

All research areas>Lymphocyte Signaling>TIRAP
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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