Anti-TNFRSF13B Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TNFRSF13B Antibody (CSB-PA023971DSR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Transmembrane activator and CAML interactor Antibody,CD267 Antibody,TNFRSF13B Antibody,TACI Antibody

More alternative names for the antibody
CD 267 antibody|CD267 antibody|CD267 antigen antibody|CVID antibody|CVID2 antibody|FLJ39942 antibody|MGC133214 antibody|MGC39952 antibody|OTTHUMP00000065442 antibody|TNFRSF 13B antibody|TNFRSF 14B antibody|TNFRSF13B antibody|TNFRSF13B protein antibody|TNFRSF14B antibody|TR13B_HUMAN antibody|Transmembrane activator and CAML interactor antibody|Tumor necrosis factor receptor 13B antibody|Tumor necrosis factor receptor superfamily member 13B antibody
Anti-TACI antibody (ab79023)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TNFRSF13B Antibody

Catalogue No.

CSB-PA023971DSR2HU

Reactivity

Human

Immunogen

Recombinant human Tumor necrosis factor receptor superfamily member 13B protein (184-293AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

31 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:23495( Human), Entrez Gene:57916( Mouse), Omim:604907( Human), SwissProt:O14836( Human), SwissProt:Q9ET35( Mouse), Unigene:158341( Human), Unigene:265915( Mouse)

Protein function

Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. .

Protein tissue specificity

Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B-cells and activated T-cells, but not in resting T-cells.

Involvement in disease

Immunodeficiency, common variable, 2 (CVID2) [MIM:240500]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Immunoglobulin A deficiency 2 (IGAD2) [MIM:609529]: Selective deficiency of immunoglobulin A (IGAD) is the most common form of primary immunodeficiency, with an incidence of approximately 1 in 600 individuals in the western world. Individuals with symptomatic IGAD often have deficiency of IgG subclasses or decreased antibody response to carbohydrate antigens such as pneumococcal polysaccharide vaccine. Individuals with IGAD also suffer from recurrent sinopulmonary and gastrointestinal infections and have an increased incidence of autoimmune disorders and of lymphoid and non-lymphoid malignancies. In vitro studies have suggested that some individuals with IGAD have impaired isotype class switching to IgA and others may have a post-switch defect. IGAD and CVID have been known to coexist in families. Some individuals initially present with IGAD1 and then develop CVID. These observations suggest that some cases of IGAD and CVID may have a common etiology. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein cellular localization

Membrane; Single-pass type III membrane protein.

Research area

All research areas>Membrane Receptors>TACI
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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