Anti-TNFRSF21 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TNFRSF21 Antibody (CSB-PA023979DSR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Death receptor 6 Antibody,CD358 Antibody,TNFRSF21 Antibody,DR6 Antibody,UNQ437/PRO868 Antibody

More alternative names for the antibody
TNFRSF 21 antibody|TNFRSF21 antibody|TNFRSF21 protein antibody|TNR21_HUMAN antibody|Tumor necrosis factor receptor superfamily member 21 antibody|Tumor necrosis factor receptor superfamily member 21 precursor antibody
Anti-DR6 antibody [DR-6-04-EC] (ab14740)
Close sc-376873|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TNFRSF21 Antibody

Catalogue No.

CSB-PA023979DSR2HU

Reactivity

Human

Immunogen

Recombinant human Tumor necrosis factor receptor superfamily member 21 protein (371-655AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

71 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:27242( Human), Omim:605732( Human), SwissProt:O75509( Human), Unigene:443577( Human)

Protein function

Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. .

Protein tissue specificity

Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. .

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein .

Research area

All research areas>Membrane Receptors>DR
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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