Anti-TOPBP1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TOPBP1 Antibody (CSB-PA846078ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

DNA topoisomerase II-beta-binding protein 1 Antibody, TopBP1 Antibody,DNA topoisomerase II-binding protein 1 Antibody,TOPBP1 Antibody

More alternative names for the antibody
DNA topoisomerase 2 binding protein 1 antibody|DNA topoisomerase 2-binding protein 1 antibody|DNA topoisomerase II binding protein 1 antibody|DNA topoisomerase II binding protein antibody|DNA topoisomerase II-beta-binding protein 1 antibody|DNA topoisomerase II-binding protein 1 antibody|DNA topoisomerase IIbeta binding protein 1 antibody|Hypothetical protein KIAA0259 [Fragment] antibody|KIAA0259 antibody|TOP2BP1 antibody|TOPB1_HUMAN antibody|TOPBP 1 antibody|TopBP1 antibody|Topoisomerase (DNA) II binding protein 1 antibody|Topoisomerase II binding protein 1 antibody
Anti-TopBP1 antibody – ChIP Grade (ab2402)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TOPBP1 Antibody

Catalogue No.

CSB-PA846078ESR2HU

Reactivity

Human

Immunogen

Recombinant human DNA topoisomerase 2-binding protein 1 protein (1253-1522AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

170 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:11073( Human), Entrez Gene:235559( Mouse), Omim:607760( Human), SwissProt:Q92547( Human), SwissProt:Q6ZQF0( Mouse), Unigene:593379( Human), Unigene:259893( Mouse)

Protein function

Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042). .

Protein tissue specificity

Highly expressed in heart, brain, placenta, lung and kidney. .

Protein post-translational modifications

Phosphorylated on serine and threonine residues in response to X-ray irradiation. .; Ubiquitinated and degraded by the proteasome. X-ray irradiation reduces ubiquitination. .

Protein cellular localization

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Note=Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AFX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Localizes to sites of DNA damage in a H2AX- independent manner. .

Research area

All research areas>Signaling Intermediates>TopBP1
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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