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Rabbit Anti-TP53BP1 Antibody (CSB-PA613268ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Tumor suppressor p53-binding protein 1 Antibody,53BP1 Antibody,p53-binding protein 1 Antibody,p53BP1 Antibody,TP53BP1 AntibodyMore alternative names for the antibody
53 BP1 antibody|53BP1 antibody|FLJ41424 antibody|MGC138366 antibody|p202 antibody|p53 binding protein 1 antibody|p53 BP1 antibody|p53-binding protein 1 antibody|p53BP1 antibody|TP53 BP1 antibody|TP53B_HUMAN antibody|Tp53bp1 antibody|TRP53 BP1 antibody|Tumor protein 53 binding protein 1 antibody|Tumor protein p53 binding protein 1 antibody|Tumor suppressor p53 binding protein 1 antibody|Tumor suppressor p53-binding protein 1 antibody
Anti-53BP1 antibody (ab36823)
Anti-53BP1 antibody (ab36823)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Tumor suppressor p53-binding protein 1 protein (1758-1972AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. .
|Involvement in disease|| |
Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. .
|Protein sequence and domain|| |
The Tudor-like region mediates binding to H4K20me2.
|Protein post-translational modifications|| |
Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding. .; Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation. Dephosphorylated by PPP5C. .
|Protein cellular localization|| |
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. H4K20me2 is required for efficient localization to double strand breaks and removal of proteins that have a high affinity for H4K20me2 such as L3MBTL1 and KDM4A is needed.
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CUSABIO BIOTECH CO.
|Product type|| |
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