Anti-TP53BP1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Anti-TP53BP1 Antibody (CSB-PA613268ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Tumor suppressor p53-binding protein 1 Antibody,53BP1 Antibody,p53-binding protein 1 Antibody,p53BP1 Antibody,TP53BP1 Antibody

More alternative names for the antibody
53 BP1 antibody|53BP1 antibody|FLJ41424 antibody|MGC138366 antibody|p202 antibody|p53 binding protein 1 antibody|p53 BP1 antibody|p53-binding protein 1 antibody|p53BP1 antibody|TP53 BP1 antibody|TP53B_HUMAN antibody|Tp53bp1 antibody|TRP53 BP1 antibody|Tumor protein 53 binding protein 1 antibody|Tumor protein p53 binding protein 1 antibody|Tumor suppressor p53 binding protein 1 antibody|Tumor suppressor p53-binding protein 1 antibody
Anti-53BP1 antibody (ab36823)
Close sc-135749|sc-135748|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TP53BP1 Antibody

Catalogue No.

CSB-PA613268ESR1HU

Reactivity

Human

Immunogen

Recombinant human Tumor suppressor p53-binding protein 1 protein (1758-1972AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

213 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:7158( Human), Entrez Gene:27223( Mouse), Omim:605230( Human), SwissProt:Q12888( Human), SwissProt:P70399( Mouse), Unigene:440968( Human), Unigene:383499( Mouse), Unigene:481841( Mouse)

Protein function

Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. .

Involvement in disease

Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. .

Protein sequence and domain

The Tudor-like region mediates binding to H4K20me2.

Protein post-translational modifications

Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding. .; Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation. Dephosphorylated by PPP5C. .

Protein cellular localization

Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. H4K20me2 is required for efficient localization to double strand breaks and removal of proteins that have a high affinity for H4K20me2 such as L3MBTL1 and KDM4A is needed.

Research area

All research areas>Tumor Suppressor/Apoptosis>53bp
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!