Anti-TP53BP2 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TP53BP2 Antibody (CSB-PA622676ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Bcl2-binding protein Antibody,Bbp Antibody,Renal carcinoma antigen NY-REN-51 Antibody,Tumor suppressor p53-binding protein 2 Antibody,53BP2 Antibody,p53-binding protein 2 Antibody,p53BP2 Antibody,TP53BP2 Antibody,ASPP2 Antibody, BBP Antibody

More alternative names for the antibody
53BP2 antibody|Apoptosis stimulating of p53 protein 2 antibody|Apoptosis stimulating protein of p53 2 antibody|Apoptosis-stimulating of p53 protein 2 antibody|ASPP2 antibody|ASPP2_HUMAN antibody|BBP antibody|Bcl2 binding protein antibody|Bcl2-binding protein antibody|NY REN 51 antigen antibody|p53 binding protein 2 antibody|p53-binding protein 2 antibody|p53BP2 antibody|PPP1R13A antibody|Renal carcinoma antigen NY-REN-51 antibody|Tp53bp2 antibody|Tumor protein p53 binding protein 2 antibody|Tumor suppressor p53 binding protein 2 antibody|Tumor suppressor p53-binding protein 2 antibody
Anti-53BP2/ASPP2 antibody [EPR13837] (ab181377)
Close sc-135818|sc-53861|sc-398311|

Recommended applications: ELISA, WB

Recommended dilution: Recommended dilution:WB:1:200-1000

Recommended protocols: check protocols

Name

Anti-TP53BP2 Antibody

Catalogue No.

CSB-PA622676ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Apoptosis-stimulating of p53 protein 2 protein (360-600AA)

Host

Rabbit

Applications

ELISA, WB

Recommended dilution

Recommended dilution:WB:1:200-1000

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

125 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:7159( Human), Omim:602143( Human), SwissProt:Q13625( Human), Unigene:523968( Human)

Protein function

Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. .

Protein tissue specificity

Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines. .

Protein sequence and domain

Belongs to the ASPP family. The ankyrin repeats and the SH3 domain are required for a specific interactions with TP53.

Protein cellular localization

Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42.

Research area

All research areas>Tumor Suppressor/Apoptosis>53bp
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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