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Rabbit Anti-TRIM13 Antibody (CSB-PA024450ESR2HU)
Supplier: CUSABIO BIOTECH CO.
E3 ubiquitin-protein ligase TRIM13 Antibody,B-cell chronic lymphocytic leukemia tumor suppressor Leu5 Antibody,Leukemia-associated protein 5 Antibody,Putative tumor suppressor RFP2 Antibody,RING finger protein 77 Antibody,Ret finger protein 2 Antibody,Tripartite motif-containing protein 13 Antibody,TRIM13 Antibody,LEU5 Antibody,RFP2 Antibody,RNF77 AntibodyMore alternative names for the antibody
B cell chronic lymphocytic leukemia tumor suppressor Leu5 antibody|B-cell chronic lymphocytic leukemia tumor suppressor Leu5 antibody|CAR antibody|DLEU5 antibody|E3 ubiquitin-protein ligase TRIM13 antibody|HGNC:9976 antibody|LEU5 antibody|Leukemia associated protein 5 antibody|Leukemia-associated protein 5 antibody|Putative tumor suppressor RFP2 antibody|Ret finger protein 2 antibody|RING finger protein 77 antibody|RNF77 antibody|TRI13_HUMAN antibody|Trim13 antibody|Tripartite motif protein 13 antibody|Tripartite motif-containing protein 13 antibody
Anti-RFP2 antibody (ab42502)
Anti-RFP2 antibody (ab42502)
Recommended applications: ELISA, WB, IHC
Recommended dilution: User optimized
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human E3 ubiquitin-protein ligase TRIM13 protein (40-310AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:535190( Cow), Entrez Gene:10206( Human), Entrez Gene:66597( Mouse), Entrez Gene:364398( Rat), Omim:605661( Human), SwissProt:Q32L60( Cow), SwissProt:O60858( Human), SwissProt:Q9CYB0( Mouse), SwissProt:Q5M7V1( Rat), Unigene:436922( Human), Unigene:23959( Mouse), Unigene:83735( Rat)
|Protein function|| |
E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. .
|Protein sequence and domain|| |
Belongs to the TRIM/RBCC family. The coiled-coil domain is required for the induction of autophagy during endoplasmic reticulum (ER) stress.; The RING-type zinc finger is required for auto-polyubiquitination.; The C-terminal domain transmembrane domain is indispensable for the localization to the ER.
|Protein post-translational modifications|| |
Auto-ubiquitinated; requires the RING-type zinc finger. Auto-polyubiquitination leads to proteasomal degradation. .
|Protein cellular localization|| |
Endoplasmic reticulum membrane ; Single-pass membrane protein . Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum.
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CUSABIO BIOTECH CO.
|Product type|| |
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