Anti-TRIM27 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TRIM27 Antibody (CSB-PA024464ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

RING finger protein 76 Antibody,Ret finger protein Antibody,Tripartite motif-containing protein 27 Antibody,TRIM27 Antibody,RFP Antibody,RNF76 Antibody

More alternative names for the antibody
AW538890 antibody|DAAP-182E11.3 antibody|MGC189472 antibody|OTTHUMP00000029314 antibody|Ret finger protein antibody|RFP antibody|RFP transforming protein antibody|Rfp1 antibody|RING finger protein 76 antibody|RNF76 antibody|TRI27_HUMAN antibody|TRIM 27 antibody|Trim27 antibody|Tripartite motif containing 27 antibody|Tripartite motif containing protein 27 antibody|Tripartite motif protein TRIM27 antibody|Tripartite motif-containing protein 27 antibody|Zinc finger protein RFP antibody
Anti-TRIM27 antibody (ab78393)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TRIM27 Antibody

Catalogue No.

CSB-PA024464ESR2HU

Reactivity

Human

Immunogen

Recombinant human Zinc finger protein RFP protein (214-513AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

58 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:520111( Cow), Entrez Gene:5987( Human), Entrez Gene:19720( Mouse), Entrez Gene:291171( Rat), Omim:602165( Human), SwissProt:P14373( Human), SwissProt:Q62158( Mouse), Unigene:440382( Human), Unigene:314056( Mouse)

Protein function

E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of ‘Lys-48’-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of ‘Lys-63’-linked polyubiquitin chains at ‘Lys-220’ of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. .

Protein tissue specificity

Expressed in testis namely within the seminiferous tubules. .

Involvement in disease

Note=A chromosomal aberration involving TRIM27/RFP is found in papillary thyroid carcinomas (PTCs). Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta TRIM27/RET oncogenes. .

Protein sequence and domain

Belongs to the TRIM/RBCC family. The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6.

Protein cellular localization

Nucleus . Cytoplasm . Nucleus, PML body . Early endosome . Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2 (PubMed:23452853). .

Research area

All research areas>Signaling Intermediates>TRIM
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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