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Rabbit Anti-TRIM27 Antibody (CSB-PA024464ESR2HU)
Supplier: CUSABIO BIOTECH CO.
RING finger protein 76 Antibody,Ret finger protein Antibody,Tripartite motif-containing protein 27 Antibody,TRIM27 Antibody,RFP Antibody,RNF76 AntibodyMore alternative names for the antibody
AW538890 antibody|DAAP-182E11.3 antibody|MGC189472 antibody|OTTHUMP00000029314 antibody|Ret finger protein antibody|RFP antibody|RFP transforming protein antibody|Rfp1 antibody|RING finger protein 76 antibody|RNF76 antibody|TRI27_HUMAN antibody|TRIM 27 antibody|Trim27 antibody|Tripartite motif containing 27 antibody|Tripartite motif containing protein 27 antibody|Tripartite motif protein TRIM27 antibody|Tripartite motif-containing protein 27 antibody|Zinc finger protein RFP antibody
Anti-TRIM27 antibody (ab78393)
Anti-TRIM27 antibody (ab78393)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Zinc finger protein RFP protein (214-513AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:520111( Cow), Entrez Gene:5987( Human), Entrez Gene:19720( Mouse), Entrez Gene:291171( Rat), Omim:602165( Human), SwissProt:P14373( Human), SwissProt:Q62158( Mouse), Unigene:440382( Human), Unigene:314056( Mouse)
|Protein function|| |
E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of ‘Lys-48’-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of ‘Lys-63’-linked polyubiquitin chains at ‘Lys-220’ of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. .
|Protein tissue specificity|| |
Expressed in testis namely within the seminiferous tubules. .
|Involvement in disease|| |
Note=A chromosomal aberration involving TRIM27/RFP is found in papillary thyroid carcinomas (PTCs). Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta TRIM27/RET oncogenes. .
|Protein sequence and domain|| |
Belongs to the TRIM/RBCC family. The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6.
|Protein cellular localization|| |
Nucleus . Cytoplasm . Nucleus, PML body . Early endosome . Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2 (PubMed:23452853). .
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CUSABIO BIOTECH CO.
|Product type|| |
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