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Rabbit Anti-TRIM32 Antibody (CSB-PA614389ESR2HU)
Supplier: CUSABIO BIOTECH CO.
E3 ubiquitin-protein ligase TRIM32 Antibody,72 kDa Tat-interacting protein Antibody,Tripartite motif-containing protein 32 Antibody,Zinc finger protein HT2A Antibody,TRIM32 Antibody,HT2A AntibodyMore alternative names for the antibody
72 kda Tat interacting Protein antibody|72 kDa Tat-interacting protein antibody|BBS11 antibody|E3 ubiquitin-protein ligase TRIM32 antibody|HT2A antibody|LGMD2H antibody|Limb girdle muscular dystrophy 2H (autosomal recessive) antibody|Limb girdle muscular dystrophy 2H antibody|Muscular dystrophy Hutterite type antibody|TAT interactive protein 72KD antibody|TATIP antibody|TRI32_HUMAN antibody|Trim32 antibody|Tripartite Motif Containing Protein 32 antibody|Tripartite motif-containing protein 32 antibody|Zinc finger protein HT2A antibody
Anti-TRIM32 antibody (ab96612)
Anti-TRIM32 antibody (ab96612)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human E3 ubiquitin-protein ligase TRIM32 protein (1-280AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=521975" target="_blank">Entrez Gene:521975( Cow)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22954" target="_blank">Entrez Gene:22954( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=69807" target="_blank">Entrez Gene:69807( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=313264" target="_blank">Entrez Gene:313264( Rat)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/602290" target="_blank">Omim:602290( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q13049" target="_blank">SwissProt:Q13049( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q8CH72" target="_blank">SwissProt:Q8CH72( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=591910" target="_blank">Unigene:591910( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=22786" target="_blank">Unigene:22786( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Rn&CID=4118" target="_blank">Unigene:4118( Rat)</a>
|Protein function|| |
Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo. .
|Protein tissue specificity|| |
Spleen, thymus, prostate, testis, ovary, intestine, colon and skeletal muscle. .
|Involvement in disease|| |
Limb-girdle muscular dystrophy 2H (LGMD2H) [MIM:254110]: An autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Bardet-Biedl syndrome 11 (BBS11) [MIM:615988]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. . Note=The disease is caused by mutations affecting the gene represented in this entry. It has been suggested that TRIM32 might be the E3 ubiquitin ligase for BBS2, a component of the BBSome complex involved in ciliogenesis, that is ubiquitinated and degraded by the proteasome (PubMed:22500027). .
|Protein sequence and domain|| |
Belongs to the TRIM/RBCC family.
|Protein post-translational modifications|| |
|Protein cellular localization|| |
Cytoplasm. Note=Localized in cytoplasmic bodies, often located around the nucleus.
|Research area|| |
<a href="https://antibodyplus.com/research-areas/">All research areas</a>><a href="https://antibodyplus.com/Signaling-Intermediates/">Signaling Intermediates</a>><a href="https://antibodyplus.com/product-tag/TRIM/">TRIM</a><br><a href="https://antibodyplus.com/product-tag/Signaling-Intermediates/"> (View all antibody categories related to Signaling Intermediates)</a>
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CUSABIO BIOTECH CO.
|Product type|| |
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