Anti-TRIM32 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TRIM32 Antibody (CSB-PA614389ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

E3 ubiquitin-protein ligase TRIM32 Antibody,72 kDa Tat-interacting protein Antibody,Tripartite motif-containing protein 32 Antibody,Zinc finger protein HT2A Antibody,TRIM32 Antibody,HT2A Antibody

More alternative names for the antibody
72 kda Tat interacting Protein antibody|72 kDa Tat-interacting protein antibody|BBS11 antibody|E3 ubiquitin-protein ligase TRIM32 antibody|HT2A antibody|LGMD2H antibody|Limb girdle muscular dystrophy 2H (autosomal recessive) antibody|Limb girdle muscular dystrophy 2H antibody|Muscular dystrophy Hutterite type antibody|TAT interactive protein 72KD antibody|TATIP antibody|TRI32_HUMAN antibody|Trim32 antibody|Tripartite Motif Containing Protein 32 antibody|Tripartite motif-containing protein 32 antibody|Zinc finger protein HT2A antibody
Anti-TRIM32 antibody (ab96612)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TRIM32 Antibody

Catalogue No.

CSB-PA614389ESR1HU

Reactivity

Human

Immunogen

Recombinant human E3 ubiquitin-protein ligase TRIM32 protein (1-280AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

71 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:521975( Cow), Entrez Gene:22954( Human), Entrez Gene:69807( Mouse), Entrez Gene:313264( Rat), Omim:602290( Human), SwissProt:Q13049( Human), SwissProt:Q8CH72( Mouse), Unigene:591910( Human), Unigene:22786( Mouse), Unigene:4118( Rat)

Protein function

Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo. .

Protein tissue specificity

Spleen, thymus, prostate, testis, ovary, intestine, colon and skeletal muscle. .

Involvement in disease

Limb-girdle muscular dystrophy 2H (LGMD2H) [MIM:254110]: An autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Bardet-Biedl syndrome 11 (BBS11) [MIM:615988]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. . Note=The disease is caused by mutations affecting the gene represented in this entry. It has been suggested that TRIM32 might be the E3 ubiquitin ligase for BBS2, a component of the BBSome complex involved in ciliogenesis, that is ubiquitinated and degraded by the proteasome (PubMed:22500027). .

Protein sequence and domain

Belongs to the TRIM/RBCC family.

Protein post-translational modifications

Ubiquitinated. .

Protein cellular localization

Cytoplasm. Note=Localized in cytoplasmic bodies, often located around the nucleus.

Research area

All research areas>Signaling Intermediates>TRIM
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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