Anti-TRIP12 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TRIP12 Antibody (CSB-PA617924ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

E3 ubiquitin-protein ligase TRIP12 Antibody,E3 ubiquitin-protein ligase for Arf Antibody,ULF Antibody,Thyroid receptor-interacting protein 12 Antibody,TR-interacting protein 12 Antibody,TRIP-12 Antibody,TRIP12 Antibody,KIAA0045 Antibody,ULF Antibody

More alternative names for the antibody
KIAA0045 antibody|MGC138849 antibody|MGC138850 antibody|Thyroid hormone receptor interactor 12 antibody|Thyroid receptor interacting protein 12 antibody|TRIP 12 antibody
Anti-TRIP12 antibody (ab86220)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TRIP12 Antibody

Catalogue No.

CSB-PA617924ESR2HU

Reactivity

Human

Immunogen

Recombinant human E3 ubiquitin-protein ligase TRIP12 protein (1-240AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

220 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:9320( Human), Omim:604506( Human), SwissProt:Q14669( Human)

Protein function

E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of ‘Lys-63’-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. .

Protein sequence and domain

Belongs to the UPL family. K-HECT subfamily.

Protein cellular localization

Nucleus, nucleoplasm .

Research area

All research areas>Signaling Intermediates>TRIP12
(View all antibody categories related to Signaling Intermediates)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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