Anti-TRPM2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TRPM2 Antibody (CSB-PA025084ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Estrogen-responsive element-associated gene 1 protein Antibody,Long transient receptor potential channel 2 Antibody,LTrpC-2 Antibody,LTrpC2 Antibody,Transient receptor potential channel 7 Antibody,TRPM2 Antibody,EREG1 Antibody, KNP3 Antibody, LTRPC2 Antibody, TRPC7 Antibody

More alternative names for the antibody
EREG 1 antibody|EREG1 antibody|Estrogen responsive element associated gene 1 antibody|Estrogen responsive element associated gene 1 protein antibody|Estrogen-responsive element-associated gene 1 protein antibody|KNP 3 antibody|KNP3 antibody|Long transient receptor potential channel 2 antibody|LTRPC 2 antibody|LTrpC-2 antibody|LTrpC2 antibody|MGC133383 antibody|NUDT9H antibody|NUDT9L1 antibody|putative Ca2+ channel protein antibody|putative Ca2+ channel protein antibody|Transient receptor potential cation channel subfamily M member 2 antibody|Transient receptor potential channel 7 antibody|TRPC 7 antibody|TrpC7 antibody|TRPM 2 antibody|Trpm2 antibody|TRPM2_HUMAN antibody
Anti-TRPM2 antibody (ab11168)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TRPM2 Antibody

Catalogue No.

CSB-PA025084ESR1HU

Reactivity

Human

Immunogen

Recombinant human Transient receptor potential cation channel subfamily M member 2 protein (1204-1503AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

171 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:7226( Human), Entrez Gene:28240( Mouse), Entrez Gene:294329( Rat), Omim:603749( Human), SwissProt:O94759( Human), SwissProt:Q5KTC0( Mouse), SwissProt:Q91YD4( Mouse), SwissProt:Q5G856( Rat), Unigene:369759( Human), Unigene:276762( Mouse), Unigene:214495( Rat)

Protein function

Isoform 1: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11960981, PubMed:12594222, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:20660597, PubMed:27383051, PubMed:27068538). Extracellular calcium passes through the channel and increases channel activity by binding to the cytoplasmic domain and stabilizing the channel in an open conformation (PubMed:19171771). Also contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (PubMed:25562606, PubMed:27068538). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Activated by intracellular ADP-ribose, beta-NAD (NAD(+)) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species (PubMed:11960981, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:27383051, PubMed:27068538). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2′-phosphate (PubMed:20650899, PubMed:25918360). Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius) (PubMed:22493272). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (By similarity). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca(2+) and Zn(2+) levels (PubMed:27068538). Confers susceptibility to cell death following oxidative stress (PubMed:12594222, PubMed:25562606). .; Isoform 2: Lacks cation channel activity. Does not mediate cation transport in response to oxidative stress or ADP-ribose. .; Isoform 3: Lacks cation channel activity and negatively regulates the channel activity of isoform 1. Negatively regulates susceptibility to cell death in reposponse to oxidative stress. .

Protein tissue specificity

Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes. .

Protein sequence and domain

Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. The cytosolic nudix box binds ADP-ribose and is required for channel activation by ADP-ribose (PubMed:15561722, PubMed:16601673).

Protein cellular localization

Cell membrane ; Multi-pass membrane protein . Perikaryon . Cell projection . Cytoplasmic vesicle . Lysosome . Note=Detected at the cell membrane and in intracellular vesicles in cortical neurons. Detected on neuronal cell bodies and neurites (By similarity). Detected on the cell membrane in polymorphonuclear neutrophils. Detected on cytoplasmic vesicles and lysosomes in immature bone marrow dendritic cells (By similarity). .; Isoform 1: Cell membrane ; Multi-pass membrane protein .; Isoform 2: Cell membrane ; Multi-pass membrane protein .; Isoform 3: Cell membrane ; Multi-pass membrane protein .

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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