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Rabbit Anti-TRPM4 Antibody (CSB-PA819465ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Transient receptor potential cation channel subfamily M member 4 Antibody,hTRPM4 Antibody,Calcium-activated non-selective cation channel 1 Antibody,Long transient receptor potential channel 4 Antibody,LTrpC-4 Antibody,LTrpC4 Antibody,Melastatin-4 Antibody,TRPM4 Antibody,LTRPC4 AntibodyMore alternative names for the antibody
1110030C19Rik antibody|AW047689 antibody|Calcium-activated non-selective cation channel 1 antibody|FLJ20041 antibody|hTRPM4 antibody|Long transient receptor potential channel 4 antibody|LTrpC-4 antibody|LTrpC4 antibody|Melastatin 4 antibody|Melastatin like 2 protein antibody|Melastatin-4 antibody|Melastatin-like 2 antibody|Mls2s antibody|PFHB1B antibody|Transient receptor potential cation channel subfamily M member 4 antibody|Transient receptor potential cation channel, subfamily M, member 4 antibody|Trpm4 antibody|TRPM4_HUMAN antibody|TRPM4B antibody
Anti-TRPM4 antibody (ab106200)
Anti-TRPM4 antibody (ab106200)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Transient receptor potential cation channel subfamily M member 4 protein (1-240AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. .
|Protein tissue specificity|| |
Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells. .
|Involvement in disease|| |
Progressive familial heart block 1B (PFHB1B) [MIM:604559]: A cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrio-ventricular block causing syncope and sudden death. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM4 sub-subfamily.
|Protein post-translational modifications|| |
Phosphorylation by PKC leads to increase the sensitivity to Ca(2+). .; Sumoylated. Desumoylated by SENP1. .
|Protein cellular localization|| |
Isoform 1: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus.; Isoform 2: Endoplasmic reticulum. Golgi apparatus.
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CUSABIO BIOTECH CO.
|Product type|| |
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