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Rabbit Anti-TRPM8 Antibody (CSB-PA768757ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Long transient receptor potential channel 6 Antibody,LTrpC-6 Antibody, LTrpC6 Antibody,Transient receptor potential p8 Antibody,Trp-p8 Antibody,TRPM8 Antibody,LTRPC6 Antibody, TRPP8 AntibodyMore alternative names for the antibody
Long transient receptor potential channel 6 antibody|LTrpC-6 antibody|LTrpC6 antibody|MGC2849 antibody|Short form of the TRPM8 cationic channel antibody|Transient receptor potential cation channel subfamily M member 8 antibody|Transient receptor potential p8 antibody|transient receptor potential-p8 antibody|Trp p8 antibody|Trp-p8 antibody|Trpm8 antibody|TRPM8_HUMAN antibody|TRPP8 antibody
Anti-TRPM8 antibody (ab3243)
Anti-TRPM8 antibody (ab3243)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Transient receptor potential cation channel subfamily M member 8 protein (980-1104AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel. .
|Protein tissue specificity|| |
Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors. .
|Protein sequence and domain|| |
Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. The coiled coil region is required for multimerization.
|Protein cellular localization|| |
Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane. Note=Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts (By similarity). Located in the endoplasmic reticulum in prostate cancer cells. .
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CUSABIO BIOTECH CO.
|Product type|| |
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