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Rabbit Anti-TSEN2 Antibody (CSB-PA850858DSR2HU)
Supplier: CUSABIO BIOTECH CO.
tRNA-intron endonuclease Sen2 Antibody,HsSen2 Antibody,TSEN2 Antibody,SEN2 AntibodyMore alternative names for the antibody
HsSen2 antibody|MGC2776 antibody|MGC4440 antibody|SEN2 antibody|SEN2_HUMAN antibody|SEN2L antibody|tRNA intron endonuclease Sen2 antibody|tRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae) antibody|tRNA splicing endonuclease subunit Sen2 antibody|tRNA-intron endonuclease sen2 antibody|tRNA-splicing endonuclease subunit Sen2 antibody|TSEN 2 antibody|TSEN2 antibody
Anti-TSEN2 antibody (ab69179)
Anti-TSEN2 antibody (ab69179)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:200-1000,IHC:1:50-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human tRNA-splicing endonuclease subunit Sen2 protein (1-220AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5′- and 3′-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2′,3′-cyclic phosphate and 5′-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5′-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3′-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3′-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity. .
|Protein tissue specificity|| |
Isoform 1 and isoform 2 are widely expressed at very low level. .
|Involvement in disease|| |
Pontocerebellar hypoplasia 2B (PCH2B) [MIM:612389]: A disorder characterized by an abnormally small cerebellum and brainstem, and progressive microcephaly from birth combined with extrapyramidal dyskinesia. Severe chorea occurs and epilepsy is frequent. There are no signs of spinal cord anterior horn cells degeneration. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the tRNA-intron endonuclease family.
|Protein cellular localization|| |
Nucleus . Nucleus, nucleolus . Note=May be transiently localized in the nucleolus.
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CUSABIO BIOTECH CO.
|Product type|| |
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