Anti-TTBK2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TTBK2 Antibody (CSB-PA753711DSR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

TTBK2 Antibody

More alternative names for the antibody
KIAA0847 antibody|mKIAA0847 antibody|SCA11 antibody|Spinocerebellar ataxia 11 antibody|Tau tubulin kinase 2 antibody|Tau-tubulin kinase 2 antibody|TTBK antibody|TTBK 2 antibody|TTBK1 antibody|TTBK2 antibody|TTBK2_HUMAN antibody|TTK antibody
Anti-Tau tubulin kinase 2 antibody – N-terminal (ab170799)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TTBK2 Antibody

Catalogue No.

CSB-PA753711DSR1HU

Reactivity

Human

Immunogen

Recombinant human Tau-tubulin kinase 2 protein (1185-1244AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

137 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:146057( Human), Omim:611695( Human), SwissProt:Q6IQ55( Human), Unigene:646511( Human), Unigene:727864( Human)

Protein function

Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. .

Involvement in disease

Spinocerebellar ataxia 11 (SCA11) [MIM:604432]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.

Protein cellular localization

Cell projection, cilium . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytosol. Nucleus. Note=Localizes to the transition zone in primary cilia in response to cell cycle signals that promote ciliogenesis (By similarity). May also be present in cytosol and, at lower level in the nucleus. .

Research area

All research areas>Signaling Intermediates>SCA11
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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