Anti-TWIST2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-TWIST2 Antibody (CSB-PA848823DSR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Twist-related protein 2 Antibody,Class A basic helix-loop-helix protein 39 Antibody,bHLHa39 Antibody,Dermis-expressed protein 1 Antibody,Dermo-1 Antibody,TWIST2 Antibody,BHLHA39 Antibody,DERMO1 Antibody

More alternative names for the antibody
bHLHa39 antibody|Twist2 antibody|TWST2_HUMAN antibody
Anti-Twist2 antibody (ab66031)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-TWIST2 Antibody

Catalogue No.

CSB-PA848823DSR1HU

Reactivity

Human

Immunogen

Recombinant human Twist-related protein 2 protein (1-70AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

18 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:117581( Human), Entrez Gene:13345( Mouse), Entrez Gene:59327( Rat), Omim:607556( Human), SwissProt:Q8WVJ9( Human), SwissProt:Q9D030( Mouse), SwissProt:P97831( Rat), Unigene:422585( Human), Unigene:9474( Mouse), Unigene:16279( Rat)

Protein function

Binds to the E-box consensus sequence 5′-CANNTG-3′ as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. .

Protein tissue specificity

In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liver. Expression also detected in the secretory ependymal epithelium of the choroid plexus primordium. In the adult, expressed in secreting glandular tissues and tubules. .

Involvement in disease

Focal facial dermal dysplasia 3, Setleis type (FFDD3) [MIM:227260]: A form of focal facial dermal dysplasia, a group of developmental defects characterized by bitemporal or preauricular skin lesions resembling aplasia cutis congenita. FFDD3 is characterized by distinctive bitemporal scar-like depressions resembling forceps marks, and additional facial features, including a coarse and leonine appearance, absent eyelashes on both lids or multiple rows on the upper lids, absent Meibomian glands, slanted eyebrows, chin clefting, and hypo- or hyperpigmentation of the skin. Histologically, the bitemporal lesion is an ectodermal dysplasia with near absence of subcutaneous fat, suggesting insufficient migration of neural crest cells into the frontonasal process and the first branchial arch. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Ablepharon-macrostomia syndrome (AMS) [MIM:200110]: A congenital ectodermal dysplasia characterized by absent eyelids, macrostomia, microtia, redundant skin, sparse hair, dysmorphic nose and ears, variable abnormalities of the nipples, genitalia, fingers, and hands, largely normal intellectual and motor development, and poor growth. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Barber-Say syndrome (BBRSAY) [MIM:209885]: A rare ectodermal dysplasia characterized by ectropion, macrostomia, ear abnormalities, broad nasal bridge, bulbous nose, redundant skin, hypertrichosis, dental abnormalities, and variable other features. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein cellular localization

Nucleus . Cytoplasm . Note=Mainly nuclear during embryonic development. Cytoplasmic in adult tissues.

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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