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Rabbit Anti-UCP1 Antibody (CSB-PA025554ESR2HU)
Supplier: CUSABIO BIOTECH CO.
UCP 1 Antibody,Solute carrier family 25 member 7 Antibody,Thermogenin Antibody,UCP1 Antibody,SLC25A7 Antibody,UCP AntibodyMore alternative names for the antibody
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-5000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Mitochondrial brown fat uncoupling protein 1 protein (1-307AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity). .
|Protein tissue specificity|| |
Brown adipose tissue. .
|Protein sequence and domain|| |
Belongs to the mitochondrial carrier (TC 2.A.29) family.
|Protein post-translational modifications|| |
May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects. .; May undergo ubiquitin-mediated proteasomal degradation. .
|Protein cellular localization|| |
Mitochondrion inner membrane ; Multi-pass membrane protein .
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CUSABIO BIOTECH CO.
|Product type|| |
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