Anti-UFD1L Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-UFD1L Antibody (CSB-PA842166ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Ubiquitin fusion degradation protein 1 homolog Antibody,UB fusion protein 1 Antibody,UFD1L Antibody

More alternative names for the antibody
UB fusion protein 1 antibody|Ubiquitin fusion degradation 1 like (yeast) antibody|Ubiquitin fusion degradation 1 like antibody|Ubiquitin fusion degradation protein 1 homolog antibody|UFD1 antibody|UFD1_HUMAN antibody|UFD1L antibody
Anti-UFD1L antibody (ab96648)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-UFD1L Antibody

Catalogue No.

CSB-PA842166ESR1HU

Reactivity

Human

Immunogen

Recombinant human Ubiquitin fusion degradation protein 1 homolog protein (1-307AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

34 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:7353( Human), Entrez Gene:22230( Mouse), Entrez Gene:84478( Rat), Omim:601754( Human), SwissProt:Q92890( Human), SwissProt:P70362( Mouse), SwissProt:Q9ES53( Rat), Unigene:474213( Human), Unigene:237594( Mouse), Unigene:11946( Rat)

Protein function

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). .

Protein tissue specificity

Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.

Protein sequence and domain

Belongs to the UFD1 family.

Protein cellular localization

Nucleus . Cytoplasm, cytosol .

Research area

All research areas>Synthesis and Degradation>UFD
(View all antibody categories related to Synthesis and Degradation)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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