Anti-ULK3 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ULK3 Antibody (CSB-PA750879ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Serine/threonine-protein kinase ULK3 Antibody,Unc-51-like kinase 3 Antibody,ULK3 Antibody

More alternative names for the antibody
DKFZP434C131 antibody|FLJ90566 antibody|Serine/threonine-protein kinase ULK3 antibody|Ulk3 antibody|ULK3_HUMAN antibody|unc 51 like kinase 3 (C. elegans) antibody|Unc-51-like kinase 3 antibody
Anti-ULK3 antibody [EPR4888] (ab124947)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ULK3 Antibody

Catalogue No.

CSB-PA750879ESR1HU

Reactivity

Human

Immunogen

Recombinant human Serine/threonine-protein kinase ULK3 protein (44-240AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

53 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:25989( Human), Omim:613472( Human), SwissProt:Q6PHR2( Human), Unigene:513034( Human)

Protein function

Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. .

Protein tissue specificity

Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord. .

Protein sequence and domain

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.

Protein post-translational modifications

Autophosphorylated. Autophosphorylation is blocked by interaction with SUFU. .

Protein cellular localization

Cytoplasm . Note=Localizes to pre-autophagosomal structure during cellular senescence.

Research area

All research areas>Kinases and Phosphatases>ULK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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