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Rabbit Anti-USP15 Antibody (CSB-PA896515DSR2HU)
Supplier: CUSABIO BIOTECH CO.
Ubiquitin carboxyl-terminal hydrolase 15 Antibody,Deubiquitinating enzyme 15 Antibody,Ubiquitin thioesterase 15 Antibody,Ubiquitin-specific-processing protease 15 Antibody,Unph-2 Antibody,Unph4 Antibody,USP15 Antibody,KIAA0529 AntibodyMore alternative names for the antibody
Deubiquitinating enzyme 15 antibody|Deubiquitinating enzyme antibody|EC 3 1 2 15 antibody|KIAA0529 antibody|MGC131982 antibody|MGC149838 antibody|MGC74854 antibody|Ubiquitin Carboxy terminal Hydrolase 15 antibody|Ubiquitin carboxyl-terminal hydrolase 15 antibody|Ubiquitin specific peptidase 15 antibody|Ubiquitin specific processing protease 15 antibody|Ubiquitin Specific Protease 15 antibody|Ubiquitin thioesterase 15 antibody|Ubiquitin thiolesterase 15 antibody|Ubiquitin-specific-processing protease 15 antibody|UBP 15 antibody|UBP15 antibody|UBP15_HUMAN antibody|Unph 2 antibody|UNPH 4 antibody|Unph-2 antibody|Unph2 antibody|Unph4 antibody|USP 15 antibody|Usp15 antibody
Anti-USP15 antibody (ab56900)
Anti-USP15 antibody (ab56900)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Ubiquitin carboxyl-terminal hydrolase 15 protein (1-260AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as ‘Lys-48’-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. .
|Protein tissue specificity|| |
Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.
|Protein sequence and domain|| |
Belongs to the peptidase C19 family.
|Protein post-translational modifications|| |
Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome. .; Ubiquitinated, leading to degradation by the proteasome. .
|Protein cellular localization|| |
Cytoplasm . Nucleus .
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CUSABIO BIOTECH CO.
|Product type|| |
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