Anti-USP15 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-USP15 Antibody (CSB-PA896515DSR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Ubiquitin carboxyl-terminal hydrolase 15 Antibody,Deubiquitinating enzyme 15 Antibody,Ubiquitin thioesterase 15 Antibody,Ubiquitin-specific-processing protease 15 Antibody,Unph-2 Antibody,Unph4 Antibody,USP15 Antibody,KIAA0529 Antibody

More alternative names for the antibody
Deubiquitinating enzyme 15 antibody|Deubiquitinating enzyme antibody|EC 3 1 2 15 antibody|KIAA0529 antibody|MGC131982 antibody|MGC149838 antibody|MGC74854 antibody|Ubiquitin Carboxy terminal Hydrolase 15 antibody|Ubiquitin carboxyl-terminal hydrolase 15 antibody|Ubiquitin specific peptidase 15 antibody|Ubiquitin specific processing protease 15 antibody|Ubiquitin Specific Protease 15 antibody|Ubiquitin thioesterase 15 antibody|Ubiquitin thiolesterase 15 antibody|Ubiquitin-specific-processing protease 15 antibody|UBP 15 antibody|UBP15 antibody|UBP15_HUMAN antibody|Unph 2 antibody|UNPH 4 antibody|Unph-2 antibody|Unph2 antibody|Unph4 antibody|USP 15 antibody|Usp15 antibody
Anti-USP15 antibody (ab56900)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-USP15 Antibody

Catalogue No.

CSB-PA896515DSR2HU

Reactivity

Human

Immunogen

Recombinant human Ubiquitin carboxyl-terminal hydrolase 15 protein (1-260AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

112 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:9958( Human), Omim:604731( Human), SwissProt:Q9Y4E8( Human), Unigene:434951( Human)

Protein function

Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as ‘Lys-48’-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. .

Protein tissue specificity

Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.

Protein sequence and domain

Belongs to the peptidase C19 family.

Protein post-translational modifications

Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome. .; Ubiquitinated, leading to degradation by the proteasome. .

Protein cellular localization

Cytoplasm . Nucleus .

Research area

All research areas>Synthesis and Degradation>USP
(View all antibody categories related to Synthesis and Degradation)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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