Anti-USP2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Anti-USP2 Antibody (CSB-PA025710ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Ubiquitin carboxyl-terminal hydrolase 2 Antibody,41 kDa ubiquitin-specific protease Antibody,Deubiquitinating enzyme 2 Antibody,Ubiquitin thioesterase 2 Antibody,Ubiquitin-specific-processing protease 2 Antibody,USP2 Antibody,UBP41 Antibody

More alternative names for the antibody
41 kDa ubiquitin specific protease antibody|41 kDa ubiquitin-specific protease antibody|Deubiquitinating enzyme 2 antibody|Ubiquitin carboxyl terminal hydrolase 2 antibody|Ubiquitin carboxyl-terminal hydrolase 2 antibody|ubiquitin specific peptidase 2 antibody|Ubiquitin specific processing protease 2 antibody|Ubiquitin specific protease 12 antibody|Ubiquitin specific protease 9 antibody|Ubiquitin specific protease, 41kD antibody|Ubiquitin thioesterase 2 antibody|Ubiquitin thiolesterase 2 antibody|Ubiquitin-specific-processing protease 2 antibody|Ubiquitin-specific-processing protease testis antibody|UBP-t antibody|UBP2_HUMAN antibody|UBP41 antibody|USP2 antibody|USP9 antibody
Anti-USP2 antibody (ab66556)
Close

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-USP2 Antibody

Catalogue No.

CSB-PA025710ESR1HU

Reactivity

Human

Immunogen

Recombinant human Ubiquitin carboxyl-terminal hydrolase 2 protein (200-430AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

68 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:9099( Human), Entrez Gene:115771( Rat), Omim:604725( Human), SwissProt:O75604( Human), SwissProt:Q5U349( Rat), Unigene:524085( Human), Unigene:203590( Rat)

Protein function

Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity). .

Protein tissue specificity

Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level). .

Protein sequence and domain

Belongs to the peptidase C19 family. USP2 subfamily. The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity.

Protein cellular localization

Cytoplasm . Cytoplasm, perinuclear region . Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. .; Isoform 4: Nucleus .

Research area

All research areas>Synthesis and Degradation>USP
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!