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Rabbit Anti-USP2 Antibody (CSB-PA025710ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Ubiquitin carboxyl-terminal hydrolase 2 Antibody,41 kDa ubiquitin-specific protease Antibody,Deubiquitinating enzyme 2 Antibody,Ubiquitin thioesterase 2 Antibody,Ubiquitin-specific-processing protease 2 Antibody,USP2 Antibody,UBP41 AntibodyMore alternative names for the antibody
41 kDa ubiquitin specific protease antibody|41 kDa ubiquitin-specific protease antibody|Deubiquitinating enzyme 2 antibody|Ubiquitin carboxyl terminal hydrolase 2 antibody|Ubiquitin carboxyl-terminal hydrolase 2 antibody|ubiquitin specific peptidase 2 antibody|Ubiquitin specific processing protease 2 antibody|Ubiquitin specific protease 12 antibody|Ubiquitin specific protease 9 antibody|Ubiquitin specific protease, 41kD antibody|Ubiquitin thioesterase 2 antibody|Ubiquitin thiolesterase 2 antibody|Ubiquitin-specific-processing protease 2 antibody|Ubiquitin-specific-processing protease testis antibody|UBP-t antibody|UBP2_HUMAN antibody|UBP41 antibody|USP2 antibody|USP9 antibody
Anti-USP2 antibody (ab66556)
Anti-USP2 antibody (ab66556)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Ubiquitin carboxyl-terminal hydrolase 2 protein (200-430AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity). .
|Protein tissue specificity|| |
Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level). .
|Protein sequence and domain|| |
Belongs to the peptidase C19 family. USP2 subfamily. The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity.
|Protein cellular localization|| |
Cytoplasm . Cytoplasm, perinuclear region . Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. .; Isoform 4: Nucleus .
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CUSABIO BIOTECH CO.
|Product type|| |
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