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Rabbit Anti-USP28 Antibody (CSB-PA850427ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Ubiquitin carboxyl-terminal hydrolase 28 Antibody,Deubiquitinating enzyme 28 Antibody,Ubiquitin thioesterase 28 Antibody,Ubiquitin-specific-processing protease 28 Antibody,USP28 Antibody,KIAA1515 AntibodyMore alternative names for the antibody
Deubiquitinating enzyme 28 antibody|KIAA1515 antibody|Ubiquitin carboxyl terminal hydrolase 28 antibody|Ubiquitin carboxyl-terminal hydrolase 28 antibody|ubiquitin carboxyl-terminal hydrolase 28 variant 1 antibody|Ubiquitin specific peptidase 28 antibody|Ubiquitin specific processing protease 28 antibody|Ubiquitin specific protease 28 antibody|Ubiquitin thioesterase 28 antibody|Ubiquitin thiolesterase 28 antibody|Ubiquitin-specific-processing protease 28 antibody|UBP28_HUMAN antibody|USP 28 antibody|USP28 antibody|USP28 protein antibody
Anti-USP28 antibody (ab188240)
Anti-USP28 antibody (ab188240)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Ubiquitin carboxyl-terminal hydrolase 28 protein (430-580AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:57646( Human), Entrez Gene:235323( Mouse), Entrez Gene:315639( Rat), Omim:610748( Human), SwissProt:Q96RU2( Human), SwissProt:Q5I043( Mouse), SwissProt:D3ZJ96( Rat), Unigene:503891( Human), Unigene:21630( Mouse), Unigene:6599( Rat)
|Protein function|| |
Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). .
|Protein sequence and domain|| |
Belongs to the peptidase C19 family. USP28 subfamily.
|Protein post-translational modifications|| |
Degradaded upon nickel ion level or hypoxia exposure.; Phosphorylated upon DNA damage at Ser-67 and Ser-714, by ATM or ATR (PubMed:16901786). Phosphorylated by PRKD1 (PubMed:24623306). .
|Protein cellular localization|| |
Nucleus, nucleoplasm .
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|Product type|| |
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