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Rabbit Anti-USP8 Antibody (CSB-PA025752ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Deubiquitinating enzyme 8 Antibody,Ubiquitin isopeptidase Y Antibody,Ubiquitin isopeptidase Y Antibody,Ubiquitin-specific-processing protease 8 Antibody,USP8 AntibodyMore alternative names for the antibody
Deubiquitinating enzyme 8 antibody|FLJ34456 antibody|hUBPy antibody|HumORF8 antibody|KIAA0055 antibody|MGC129718 antibody|Ubiquitin carboxyl-terminal hydrolase 8 antibody|Ubiquitin isopeptidase Y antibody|ubiquitin specific peptidase 8 antibody|Ubiquitin thioesterase 8 antibody|Ubiquitin-specific-processing protease 8 antibody|UBP8_HUMAN antibody|UBPY antibody|Usp8 antibody
Anti-UBPY/USP8 antibody (ab38865)
Anti-UBPY/USP8 antibody (ab38865)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:200-1000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Ubiquitin carboxyl-terminal hydrolase 8 protein (1-270AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both ‘Lys-48’ an ‘Lys-63’-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. .
|Protein sequence and domain|| |
Belongs to the peptidase C19 family. The MIT domain is required for endosomal localization, CHMP1B-binding, maintenance of ESCRT-0 stability and EGFR degradation.; The rhodanese domain is sufficient for RNF41-binding.
|Protein post-translational modifications|| |
Phosphorylation of Ser-718 is essential for interaction with YWHAE and for cytosol localization. Undergoes dephosphorylation at Ser-718 in the M phase. Tyrosine-phosphorylated in its N-terminal half in an EGFR-dependent manner. .; Ubiquitinated. Inactive form is mostly monoubiquitinated, but polyubiquitination happens too. Ubiquitination is increased in EGF-stimulated cells. Ubiquitination of active form is undetectable, suggesting a possibility that USP8 deubiquitinates itself, thereby regulating its own function (By similarity). .
|Protein cellular localization|| |
Cytoplasm . Nucleus . Endosome membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane protein .
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CUSABIO BIOTECH CO.
|Product type|| |
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