Anti-USP8 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-USP8 Antibody (CSB-PA025752ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Deubiquitinating enzyme 8 Antibody,Ubiquitin isopeptidase Y Antibody,Ubiquitin isopeptidase Y Antibody,Ubiquitin-specific-processing protease 8 Antibody,USP8 Antibody

More alternative names for the antibody
Deubiquitinating enzyme 8 antibody|FLJ34456 antibody|hUBPy antibody|HumORF8 antibody|KIAA0055 antibody|MGC129718 antibody|Ubiquitin carboxyl-terminal hydrolase 8 antibody|Ubiquitin isopeptidase Y antibody|ubiquitin specific peptidase 8 antibody|Ubiquitin thioesterase 8 antibody|Ubiquitin-specific-processing protease 8 antibody|UBP8_HUMAN antibody|UBPY antibody|Usp8 antibody
Anti-UBPY/USP8 antibody (ab38865)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-USP8 Antibody

Catalogue No.

CSB-PA025752ESR2HU

Reactivity

Human

Immunogen

Recombinant human Ubiquitin carboxyl-terminal hydrolase 8 protein (1-270AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

127 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:9101( Human), Omim:603158( Human), SwissProt:P40818( Human), Unigene:443731( Human)

Protein function

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both ‘Lys-48’ an ‘Lys-63’-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. .

Protein sequence and domain

Belongs to the peptidase C19 family. The MIT domain is required for endosomal localization, CHMP1B-binding, maintenance of ESCRT-0 stability and EGFR degradation.; The rhodanese domain is sufficient for RNF41-binding.

Protein post-translational modifications

Phosphorylation of Ser-718 is essential for interaction with YWHAE and for cytosol localization. Undergoes dephosphorylation at Ser-718 in the M phase. Tyrosine-phosphorylated in its N-terminal half in an EGFR-dependent manner. .; Ubiquitinated. Inactive form is mostly monoubiquitinated, but polyubiquitination happens too. Ubiquitination is increased in EGF-stimulated cells. Ubiquitination of active form is undetectable, suggesting a possibility that USP8 deubiquitinates itself, thereby regulating its own function (By similarity). .

Protein cellular localization

Cytoplasm . Nucleus . Endosome membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane protein .

Research area

All research areas>Synthesis and Degradation>UBPY
(View all antibody categories related to Synthesis and Degradation)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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